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Unraveling the Endocannabinoid System: Exploring Its Therapeutic Potential in Autism Spectrum Disorder.
Jana, Ankit; Nath, Arnab; Sen, Palash; Kundu, Swikriti; Alghamdi, Badrah S; Abujamel, Turki S; Saboor, Muhammad; Woon-Khiong, Chan; Alexiou, Athanasios; Papadakis, Marios; Alam, Mohammad Zubair; Ashraf, Ghulam Md.
Afiliación
  • Jana A; Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.
  • Nath A; Department of Developmental Biology and Genetics, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
  • Sen P; School of Biosciences, Indian Institute of Technology, Kharagpur, West Bengal, 721302, India.
  • Kundu S; Siksha Bhavana, Visva-Bharati University, Bolpur, West Bengal, 731235, India.
  • Alghamdi BS; Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Abujamel TS; Department of Physiology, Neuroscience Unit, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Saboor M; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Woon-Khiong C; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Alexiou A; Department of Medical Laboratory Sciences, College of Health Sciences, and Research Institute for Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates.
  • Papadakis M; Department of Biological Sciences, National University of Singapore, Singapore, 117558, Singapore.
  • Alam MZ; University Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India.
  • Ashraf GM; Department of Research & Development, Funogen, Athens, Greece.
Neuromolecular Med ; 26(1): 20, 2024 May 14.
Article en En | MEDLINE | ID: mdl-38744725
ABSTRACT
The salient features of autism spectrum disorder (ASD) encompass persistent difficulties in social communication, as well as the presence of restricted and repetitive facets of behavior, hobbies, or pursuits, which are often accompanied with cognitive limitations. Over the past few decades, a sizable number of studies have been conducted to enhance our understanding of the pathophysiology of ASD. Preclinical rat models have proven to be extremely valuable in simulating and analyzing the roles of a wide range of established environmental and genetic factors. Recent research has also demonstrated the significant involvement of the endocannabinoid system (ECS) in the pathogenesis of several neuropsychiatric diseases, including ASD. In fact, the ECS has the potential to regulate a multitude of metabolic and cellular pathways associated with autism, including the immune system. Moreover, the ECS has emerged as a promising target for intervention with high predictive validity. Particularly noteworthy are resent preclinical studies in rodents, which describe the onset of ASD-like symptoms after various genetic or pharmacological interventions targeting the ECS, providing encouraging evidence for further exploration in this area.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endocannabinoides / Modelos Animales de Enfermedad / Trastorno del Espectro Autista Límite: Animals / Child / Humans Idioma: En Revista: Neuromolecular Med Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endocannabinoides / Modelos Animales de Enfermedad / Trastorno del Espectro Autista Límite: Animals / Child / Humans Idioma: En Revista: Neuromolecular Med Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos