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Hormesis as an adaptive response to infection.
Bauer, Michael; Ermolaeva, Maria; Singer, Mervyn; Wetzker, Reinhard; Soares, Miguel P.
Afiliación
  • Bauer M; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany. Electronic address: Michael.Bauer@med.uni-jena.de.
  • Ermolaeva M; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany; Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany.
  • Singer M; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.
  • Wetzker R; Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.
  • Soares MP; Cluster of Excellence Balance of the Microverse, Friedrich Schiller University Jena, Jena, Germany; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Trends Mol Med ; 30(7): 633-641, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38744580
ABSTRACT
Hormesis is a phenomenon whereby low-level stress can improve cellular, organ, or organismal fitness in response to a subsequent similar or other stress insult. Whereas hormesis is thought to contribute to the fitness benefits arising from symbiotic host-microbe interactions, the putative benefits of hormesis in host-pathogen interactions have yet to be explored. Hormetic responses have nonetheless been reported in experimental models of infection, a common feature of which is regulation of host mitochondrial function. We propose that these mitohormetic responses could be harnessed therapeutically to limit the severity of infectious diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Huésped-Patógeno / Hormesis / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interacciones Huésped-Patógeno / Hormesis / Mitocondrias Límite: Animals / Humans Idioma: En Revista: Trends Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido