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Harnessing exosomes in theranostic applications: advancements and insights in gastrointestinal cancer research.
Shojaeian, Ali; Naeimi Torshizi, S R; Parsapasand, Mahsa Sadat; Amjad, Zahra Sobhi; Khezrian, Ali; Alibakhshi, Abbas; Yun, Faye; Baghaei, Kaveh; Amini, Razieh; Pecic, Stevan.
Afiliación
  • Shojaeian A; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Naeimi Torshizi SR; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Parsapasand MS; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Amjad ZS; Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Khezrian A; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Alibakhshi A; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Yun F; Department of Chemistry and Biochemistry, California State University, Fullerton, USA.
  • Baghaei K; Olivia Newton-John Cancer and Research Institute, Melbourne, VIC, Australia.
  • Amini R; School of Cancer Medicine, La Trobe University, Melbourne, VIC, Australia.
  • Pecic S; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Discov Oncol ; 15(1): 162, 2024 May 14.
Article en En | MEDLINE | ID: mdl-38743146
ABSTRACT
Exosomes are small extracellular vesicles (30-150 nm) that are formed by endocytosis containing complex RNA as well as protein structures and are vital in intercellular communication and can be used in gene therapy and drug delivery. According to the cell sources of origin and the environmental conditions they are exposed to, these nanovesicles are very heterogeneous and dynamic in terms of content (cargo), size and membrane composition. Exosomes are released under physiological and pathological conditions and influence the pathogenesis of cancers through various mechanisms, including angiogenesis, metastasis, immune dysregulation, drug resistance, and tumor growth/development. Gastrointestinal cancer is one of the deadliest types of cancer in humans and can involve organs e.g., the esophagus and stomach, or others such as the liver, pancreas, small intestine, and colon. Early diagnosis is very important in this field because the overall survival of patients is low due to diagnosis in late stages and recurrence. Also, various therapeutic strategies have failed and there is an unmet need for the new therapeutic agents. Exosomes can become promising candidates in gastrointestinal cancers as biomarkers and therapeutic agents due to their lower immunity and passing the main physiological barriers. In this work, we provide a general overview of exosomes, their biogenesis and biological functions. In addition, we discuss the potential of exosomes to serve as biomarkers, agents in cancer treatment, drug delivery systems, and effective vaccines in immunotherapy, with an emphasis on gastrointestinal cancers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Discov Oncol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Discov Oncol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos