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Detailed role of mesenchymal stem cell (MSC)-derived exosome therapy in cardiac diseases.
Hassanzadeh, Ali; Shomali, Navid; Kamrani, Amin; Nasiri, Hadi; Ahmadian Heris, Javad; Pashaiasl, Maryam; Sadeghi, Mohammadreza; Sadeghvand, Shahram; Valedkarimi, Zahra; Akbari, Morteza.
Afiliación
  • Hassanzadeh A; Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Shomali N; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Kamrani A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Nasiri H; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ahmadian Heris J; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Pashaiasl M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sadeghi M; Department of Allergy and Clinical Immunology, Pediatric Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sadeghvand S; Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Valedkarimi Z; Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, P.O. Box 51376563833, Tabriz, Iran.
  • Akbari M; Department of Molecular Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
EXCLI J ; 23: 401-420, 2024.
Article en En | MEDLINE | ID: mdl-38741729
ABSTRACT
Coronary heart disease (CHD) continues to be the leading cause of morbidity and mortality. There are numerous therapeutic reperfusion methods, including thrombolytic therapy, primary percutaneous coronary intervention, and anti-remodeling drugs like angiotensin-converting enzyme inhibitors and beta-blockers. Despite this, there is no pharmacological treatment that can effectively stop cardiomyocyte death brought on by myocardial ischemia/reperfusion (I/R) injury. For the purpose of regenerating cardiac tissue, mesenchymal stem cell (MSC) therapy has recently gained more attention. The pleiotropic effects of MSCs are instead arbitrated by the secretion of soluble paracrine factors and are unrelated to their capacity for differentiation. One of these paracrine mediators is the extracellular vesicle known as an exosome. Exosomes deliver useful cargo to recipient cells from MSCs, including peptides, proteins, cytokines, lipids, miRNA, and mRNA molecules. Exosomes take part in intercellular communication processes and help tissues and organs that have been injured or are ill heal. Exosomes alone were found to be the cause of MSCs' therapeutic effects in a variety of animal models, according to studies. Here, we have focused on the recent development in the therapeutic capabilities of exosomal MSCs in cardiac diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: EXCLI J Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: EXCLI J Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Alemania