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Acute Aseptic Meningitis Temporally Associated with Intravenous Polyclonal Immunoglobulin Therapy: A Systematic Review.
De Felice, Elisabetta L T; Toti, Gabriel F; Gatti, Beatrice; Gualtieri, Renato; Camozzi, Pietro; Lava, Sebastiano A G; Milani, Gregorio P; Treglia, Giorgio; Vanoni, Federica; Bianchetti, Mario G; Bernasconi, Gianmaria F; Terziroli Beretta Piccoli, Benedetta; Lavagno, Camilla.
Afiliación
  • De Felice ELT; Family Medicine Institute, Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
  • Toti GF; Family Medicine Institute, Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
  • Gatti B; Family Medicine Institute, Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
  • Gualtieri R; Family Medicine Institute, Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
  • Camozzi P; Department of Anesthesia, Hôpital du Valais, Sion, Switzerland.
  • Lava SAG; Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
  • Milani GP; Clinical Pharmacology & Therapeutics Group, University College London, London, UK.
  • Treglia G; Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
  • Vanoni F; Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
  • Bianchetti MG; Clinic of Nuclear Medicine, Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  • Bernasconi GF; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
  • Terziroli Beretta Piccoli B; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.
  • Lavagno C; Institute of Pediatric of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Clin Rev Allergy Immunol ; 66(2): 241-249, 2024 Apr.
Article en En | MEDLINE | ID: mdl-38739354
ABSTRACT
An acute aseptic meningitis has been occasionally observed on intravenous polyclonal human immunoglobulin therapy. Since case reports cannot be employed to draw inferences about the relationships between immunoglobulin therapy and meningitis, we conducted a systematic review and meta-analysis of the literature. Eligible were cases, case series, and pharmacovigilance studies. We found 71 individually documented cases (36 individuals ≤ 18 years of age) of meningitis. Ninety percent of cases presented ≤ 3 days after initiating immunoglobulin therapy and recovered within ≤ 7 days (with a shorter disease duration in children ≤ 3 days in 29 (94%) cases). In 22 (31%) instances, the authors noted a link between the onset of meningitis and a rapid intravenous infusion of immunoglobulins. Cerebrospinal fluid analysis revealed a predominantly neutrophilic (N = 46, 66%) pleocytosis. Recurrences after re-exposure were observed in eight (N = 11%) patients. Eight case series addressed the prevalence of meningitis in 4089 patients treated with immunoglobulins. A pooled prevalence of 0.6% was noted. Finally, pharmacovigilance data revealed that meningitis temporally associated with intravenous immunoglobulin therapy occurred with at least five different products. In conclusion, intravenous immunoglobulin may cause an acute aseptic meningitis. The clinical features remit rapidly after discontinuing the medication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulinas Intravenosas / Meningitis Aséptica Límite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Clin Rev Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulinas Intravenosas / Meningitis Aséptica Límite: Adolescent / Child / Child, preschool / Humans Idioma: En Revista: Clin Rev Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos