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Language impairment in sporadic and familial (type 8) amyotrophic lateral sclerosis: A comparative study.
de Araújo, Caroline M; de Alcântara, Cássia; Alencar, Mariana A; da Gama, Natália A S; Cruzeiro, Marcelo M; França, Marcondes C; Jaeger, Antônio; Camargos, Sarah T; Machado, Thais H; de Souza, Leonardo Cruz.
Afiliación
  • de Araújo CM; Postgraduate Program in Neuroscience, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • de Alcântara C; Postgraduate Program in Neuroscience, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Alencar MA; Department of Physical Therapy, UFMG, Belo Horizonte, Brazil.
  • da Gama NAS; Postgraduate Program in Neuroscience, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Cruzeiro MM; Department of Internal Medicine, Universidade Federal de Juiz de Fora, Juiz de Fora, Brazil.
  • França MC; Department of Neurology, State University of Campinas, Campinas, Brazil.
  • Jaeger A; Department of Psychology, Faculty of Philosophy and Human Sciences, UFMG, Belo Horizonte, Brazil.
  • Camargos ST; Postgraduate Program in Neuroscience, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Machado TH; Department of Internal Medicine, School of Medicine, UFMG, Belo Horizonte, Brazil.
  • de Souza LC; Department of Speech-Language-Hearing Sciences, School of Medicine, UFMG, Belo Horizonte, Brazil.
Muscle Nerve ; 70(1): 130-139, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38738747
ABSTRACT
INTRODUCTION/

AIMS:

Language is frequently affected in patients with sporadic amyotrophic lateral sclerosis (sALS), with reduced performance in naming, syntactic comprehension, grammatical expression, and orthographic processing. However, the language profile of patients with familial type 8 ALS (ALS8), linked to p.P56S VAPB mutation, remains unclear. We investigated language in patients with ALS8 by examining their auditory comprehension and verbal production.

METHODS:

We included three groups of

participants:

(1) patients with sALS (n = 20), (2) patients with familial ALS8 (n = 22), and (3) healthy controls (n = 21). The groups were matched for age, sex, and education level. All participants underwent a comprehensive language battery, including the Boston Diagnostic Aphasia Examination, the reduced Token test, letter fluency, categorical fluency (animals), word definition from the Cambridge Semantic Memory Research Battery, and a narrative discourse analysis. Participants also were evaluated using Addenbrooke's Cognitive Exam-Revised Version, the Hospital Anxiety and Depression Scale, and the ALS Functional Rating Scale-Revised.

RESULTS:

Compared to controls, sALS and ALS8 patients had impaired performance on oral (syntactic and phonological processing) comprehension and inappropriate discourse cohesion. sALS and ALS8 did not differ in any language measure. There was no correlation between language scores and functional and psychiatric scales.

DISCUSSION:

ALS8 patients exhibit language deficits that are independent of motor features. These findings are consistent with the current evidence suggesting that ALS8 has prominent non-motor features.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esclerosis Amiotrófica Lateral Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Muscle Nerve Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos