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Research progress on the relationship between AURKA and tumorigenesis: the neglected nuclear function of AURKA.
Chen, Menghua; Zhu, Huijun; Li, Jian; Luo, Danjing; Zhang, Jiaming; Liu, Wenqi; Wang, Jue.
Afiliación
  • Chen M; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Zhu H; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Li J; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Luo D; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Zhang J; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Liu W; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
  • Wang J; Department of Radiation Oncology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ann Med ; 56(1): 2282184, 2024 12.
Article en En | MEDLINE | ID: mdl-38738386
ABSTRACT
AURKA is a threonine or serine kinase that needs to be activated by TPX2, Bora and other factors. AURKA is located on chromosome 20 and is amplified or overexpressed in many human cancers, such as breast cancer. AURKA regulates some basic cellular processes, and this regulation is realized via the phosphorylation of downstream substrates. AURKA can function in either the cytoplasm or the nucleus. It can promote the transcription and expression of oncogenes together with other transcription factors in the nucleus, including FoxM1, C-Myc, and NF-κB. In addition, it also sustains carcinogenic signaling, such as N-Myc and Wnt signaling. This article will focus on the role of AURKA in the nucleus and its carcinogenic characteristics that are independent of its kinase activity to provide a theoretical explanation for mechanisms of resistance to kinase inhibitors and a reference for future research on targeted inhibitors.
AURKA plays an important role in the control of the proliferation, invasion, cell cycle regulation and self-renewal of cancer stem cells.Small molecule kinase inhibitors targeting AURKA have been developed, but the overall response rate of patients in clinical trials is not ideal, prompting us to pay attention to the non-kinase activity of AURKA.This review focuses on the nuclear function of AURKA and its oncogenic properties independent of kinase activity, demonstrating that the nuclear substrate of AURKA and the remote allosteric site of the kinase may be targets of anticancer therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Celular / Carcinogénesis / Aurora Quinasa A Límite: Animals / Humans Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Núcleo Celular / Carcinogénesis / Aurora Quinasa A Límite: Animals / Humans Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido