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Prognostic and diagnostic effects of high serum midkine levels in patients with hepatocellular carcinoma.
Okada, Rei; Otsuka, Yuichiro; Kajiwara, Yoji; Maeda, Tetsuya; Ishii, Jun; Kimura, Kazutaka; Matsumoto, Yu; Ito, Yuko; Funahashi, Kimihiko; Shimada, Hideaki.
Afiliación
  • Okada R; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Otsuka Y; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Kajiwara Y; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Maeda T; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Ishii J; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Kimura K; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Matsumoto Y; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Ito Y; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Funahashi K; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
  • Shimada H; Department of Surgery, School of Medicine, Toho University, Ota City, Tokyo 143-8541, Japan.
Oncol Lett ; 27(6): 283, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38736738
ABSTRACT
Midkine (MK) is a soluble cytokine, and its serum levels strongly correspond to protein expression levels in tumors. The present study aimed to clarify the clinicopathological and prognostic significance of serum MK (s-MK) in patients with hepatocellular carcinoma (HCC). Serum samples were obtained before surgery from 123 patients with HCC who had undergone surgery between January 2012 and December 2020. The receiver operating characteristic curve revealed that the best cut-off value for s-MK in differentiating HCC from healthy cases was 426 pg/ml. The clinicopathological variables and overall survival of patients were compared between the s-MK-positive group and s-MK-negative group. The sensitivity, specificity and accuracy of s-MK were 82.1, 97.4 and 88.0%, respectively. An s-MK-positive status was significantly associated with the number of tumors (≥2). The positivity rate of s-MK was significantly higher compared with that of α-fetoprotein and protein-induced by vitamin K absence-II. In total, only 28% of the patients were positive for s-MK. The s-MK-positive group showed significantly worse overall survival compared with the s-MK-negative group. Moreover, multivariate analysis revealed that an s-MK-positive status was independently associated with poor prognosis. s-MK was useful in detecting early HCC. The findings of this study indicated that the s-MK-positive status is associated with the number of tumors and can act as an independent prognostic risk factor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia