Morphologic Features of Invasion in Lung Adenocarcinoma: Diagnostic Pitfalls.
Adv Anat Pathol
; 31(5): 289-302, 2024 Sep 01.
Article
en En
| MEDLINE
| ID: mdl-38736358
ABSTRACT
Reproducibility of pulmonary invasive adenocarcinoma diagnosis is poor when applying the World Health Organization (WHO) classification. In this article, we aimed first to explain by 3-dimensional morphology why simple pattern recognition induces pitfalls for the assessment of invasion as applied in the current WHO classification of pulmonary adenocarcinomas. The underlying iatrogenic-induced morphologic alterations in collapsed adenocarcinoma in situ overlap with criteria for invasive adenocarcinoma. Pitfalls in seemingly acinar and papillary carcinoma are addressed with additional cytokeratin 7 and elastin stains. In addition, we provide more stringent criteria for a better reproducible and likely generalizable classification.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenocarcinoma
/
Adenocarcinoma del Pulmón
/
Neoplasias Pulmonares
/
Invasividad Neoplásica
Límite:
Humans
Idioma:
En
Revista:
Adv Anat Pathol
Asunto de la revista:
ANATOMIA
/
PATOLOGIA
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos