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Prognostic significance and immune landscape of a cell cycle progression-related risk model in bladder cancer.
Tuo, Zhouting; Lin, Yuan; Zhang, Ying; Gao, Liang; Yu, Dexin; Wang, Jiani; Sun, Chenyu; Sun, Xianchao; Wang, Jinyou; Prasad, Apurwa; Bheesham, Nimarta; Meng, Muzi; Lv, Zhengmei; Chen, Xin.
Afiliación
  • Tuo Z; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Lin Y; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Zhang Y; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Gao L; Center for Clinical Medicine, Huatuo Institute of Medical Innovation (HTIMI), Berlin, Germany.
  • Yu D; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Wang J; Institute for Social Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin; Berlin Institute of Health, Epidemiology and Health Economics, Berlin, Germany.
  • Sun C; Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Sun X; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Wang J; Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
  • Prasad A; Parkview Regional Medical Center, 11109 Parkview Plaza Dr, Fort Wayne, IN, 46845, USA.
  • Bheesham N; Internal Medicine, University of Illinois College of Medicine, One Illini Drive, Peoria, IL, 61605, USA.
  • Meng M; UK Program Site, American University of the Caribbean School of Medicine, Vernon Building Room 64, Sizer St, Preston, PR1 1JQ, UK.
  • Lv Z; Bronxcare Health System, 1650 Grand Concourse, The Bronx, NY, 10457, USA.
  • Chen X; Department of Histology and Embryology, School of Basic Medical Sciences, Anhui Medical University, Anhui, China. lvzhengmeiayd@163.com.
Discov Oncol ; 15(1): 160, 2024 May 12.
Article en En | MEDLINE | ID: mdl-38735911
ABSTRACT

BACKGROUND:

A greater emphasis has been placed on the part of cell cycle progression (CCP) in cancer in recent years. Nevertheless, the precise connection between CCP-related genes and bladder cancer (BCa) has remained elusive. This study endeavors to establish and validate a reliable risk model incorporating CCP-related factors, aiming to predict both the prognosis and immune landscape of BCa.

METHODS:

Clinical information and RNA sequencing data were collected from the GEO and TCGA databases. Univariate and multivariate Cox regression analyses were conducted to construct a risk model associated with CCP. The performance of the model was assessed using ROC and Kaplan-Meier survival analyses. Functional enrichment analysis was employed to investigate potential cellular functions and signaling pathways. The immune landscape was characterized using CIBERSORT algorithms. Integration of the risk model with various clinical variables led to the development of a nomogram.

RESULTS:

To build the risk model, three CCP-related genes (RAD54B, KPNA2, and TPM1) were carefully chosen. ROC and Kaplan-Meier survival analysis confirm that our model has good performance. About immunological infiltration, the high-risk group showed decreased levels of regulatory T cells and dendritic cells coupled with increased levels of activated CD4 + memory T cells, M2 macrophages, and neutrophils. Furthermore, the nomogram showed impressive predictive power for OS at 1, 3, and 5 years.

CONCLUSION:

This study provides new insights into the association between the CCP-related risk model and the prognosis of BCa, as well as its impact on the immune landscape.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Discov Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Discov Oncol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos