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Prevalence and molecular characterization of hepatitis E virus (HEV) from wild rodents in Hubei Province, China.
Ding, Qingwen; Hu, Bing; Yao, Xuan; Gan, Min; Chen, Dan; Zhang, Nailou; Wei, Jinbo; Cai, Kun; Zheng, Zhenhua.
Afiliación
  • Ding Q; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
  • Hu B; Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.
  • Yao X; Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China.
  • Gan M; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
  • Chen D; College of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430024, China.
  • Zhang N; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
  • Wei J; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China.
  • Cai K; Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China. Electronic address: ckreal@163.com.
  • Zheng Z; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei 430071, China. Electronic address: zhengzh@wh.iov.cn.
Infect Genet Evol ; 121: 105602, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38734397
ABSTRACT
Hepatitis E, caused by the hepatitis E virus (HEV), is a global public health issue. Low similarity between the gene sequences of mouse and human HEV led to the belief that the risk of human infection was low. Recent reports of chronic and acute hepatitis E caused by murine HEV infection in humans in Hong Kong have raised global concerns. Therefore, it is crucial to investigate the epidemiology and prevalence of HEV in China. We comprehensively analyzed different rodent HEV strains to understand rocahepevirus occurrence in Hubei Province, China. The HEV positivity rate for was 6.43% (73/1136). We identified seven near-full-length rocahepevirus strains and detected rat HEV antigens in tissues from different mouse species. HEV has extensive tissue tropism and a high viral load in the liver. We highlight the genetic diversity of HEVs in rodents and underscore the importance of paying attention to their variation and evolution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Virus de la Hepatitis E / Hepatitis E Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Virus de la Hepatitis E / Hepatitis E Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos