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Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology.
Wang, Yi; Yin, Li; Du, Yao-Yao; Liao, Hong-Mei; Li, Juan; Yao, Wen; Yuan, Xiao-Qiong; Guo, Qing-Chun; Deng, Tao-Ran; Guo, Na; Zhang, Min; Zeng, Qiang; Liu, Chong; Li, Yu-Feng.
Afiliación
  • Wang Y; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Yin L; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Du YY; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Liao HM; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Li J; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Yao W; General Hospital of Central Theater Command, Wuhan, Hubei, PR China.
  • Yuan XQ; The Reproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
  • Guo QC; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Deng TR; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Guo N; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Zhang M; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Zeng Q; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
  • Liu C; Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China. Electronic address: chongliu31@shsmu.edu.cn.
  • Li YF; Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address: tjlyf66@126.com.
Environ Toxicol Pharmacol ; 108: 104463, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38734395
ABSTRACT
Phthalates can induce hepatotoxicity in animal studies. We aimed to assess the associations of individual and mixture of urinary phthalate metabolites with serum liver function indicators among 764 women undergoing assisted reproductive technology (ART). In linear models, we observed inverse correlations between urinary mono-benzyl phthalate and serum total protein (TP) as well as globulin (ß=-0.27 and -0.23, respectively, P<0.05). Additionally, negative associations were identified between mono-isobutyl phthalate and mono-butyl phthalate (MBP) and aspartate aminotransferase-to-alanine transaminase ratio (AST/ALT) (P<0.05). MBP and the sum of all phthalate metabolites (∑all.phth.m) were positively associated with bilirubin, with ß ranging from 0.14 to 0.47. Most phthalate metabolites were also positively related to gamma-glutamyl transferase (GGT) (all P<0.05). In Bayesian kernel machine regression models, phthalate mixture was positively associated with bilirubin and GGT, whereas inversely associated with AST/ALT and TP. Our results suggest that phthalate exposure may impair liver function among women undergoing ART.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Técnicas Reproductivas Asistidas / Hígado Límite: Adult / Female / Humans Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Técnicas Reproductivas Asistidas / Hígado Límite: Adult / Female / Humans Idioma: En Revista: Environ Toxicol Pharmacol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos