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Doxorubicin encapsulated blend of sitagliptin-lignin polymeric drug delivery system for effective combination therapy against cancer.
Liaqat, Sana; Fatima, Batool; Hussain, Dilshad; Imran, Muhammad; Zahra Jawad, Shan E; Imran, Muhammad; Saeed, Adeela; Majeed, Saadat; Najam-Ul-Haq, Muhammad.
Afiliación
  • Liaqat S; Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
  • Fatima B; Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address: batoolfatima@bzu.edu.pk.
  • Hussain D; HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
  • Imran M; Biochemistry Section, Institute of Chemical Sciences, University of Peshawar, 25120, Pakistan.
  • Zahra Jawad SE; Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
  • Imran M; Research Center for Advanced for Advanced Materials Science (RCAMS), Chemistry Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
  • Saeed A; Department of Chemistry, The Women University Multan, Multan 60000, Pakistan.
  • Majeed S; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan.
  • Najam-Ul-Haq M; Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address: najamulhaq@bzu.edu.pk.
Int J Biol Macromol ; 269(Pt 2): 132146, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38734342
ABSTRACT
In this research, a sitagliptin-lignin biopolymer (SL) containing zinc selenide quantum dots (ZnSe QDs) and doxorubicin (doxo) was synthesized. The fabricated polymeric drug delivery system was characterized via FTIR, XRD, SEM, TGA, IR, and DSC. SLQD-Doxo exhibited an irregular surface with a 32 nm diameter and well-defined surface chemistry. Drug loading efficiency was assessed at different concentrations, pH levels, time intervals, and temperatures, and drug kinetics were calculated. Maximum drug release was observed at 6 µmol concentration after 24 h, pH of 6.5 and 45 °C. The maximum drug encapsulation efficiency was 81.75 %. SLQD-Doxo demonstrated 24.4 ± 1.04 % anti-inflammatory activity, and the maximum lipoxygenase inhibition in a concentration-dependent manner was 71.45 ± 2.02 %, compared to indomethacin, a standard anticancer drug. The designed system was applied to breast cancer MCF-7 cells to evaluate anticancer activity. Cytotoxicity of SLQD-Doxo resulted in 24.48 ± 1.64 dead cells and 74.39 ± 4.12 viable cells. Lignin's polyphenolic nature resulted in good antioxidant activity of LLQD-Doxo. The combination of SLQD-Doxo was appropriate for drug delivery at high temperatures and acidic pH of tumor cells compared to healthy cells.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Sistemas de Liberación de Medicamentos / Fosfato de Sitagliptina / Lignina Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Doxorrubicina / Sistemas de Liberación de Medicamentos / Fosfato de Sitagliptina / Lignina Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Países Bajos