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Prenatal exposure to ethion caused maternal and foetal toxicity in rats.
Durom, Elizabeth Glanet; Aneesha, V A; Kumar, Nerella Venkata Pavan; Bin Azeez, Ajmi; Karikalan, M; Lingaraju, Madhu C; Parida, Subhashree; Telang, Avinash G; Singh, Thakur Uttam.
Afiliación
  • Durom EG; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
  • Aneesha VA; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India. Electronic address: draneeshava@gmail.com.
  • Kumar NVP; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
  • Bin Azeez A; Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
  • Karikalan M; Centre for Wildlife Conservation, Management and Disease Surveillance, ICAR-Indian Veterinary Research Institute, Izatnagar, 243122, UP, India.
  • Lingaraju MC; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
  • Parida S; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
  • Telang AG; Centre for Animal Disease Research and Diagnosis (CADRAD), ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
  • Singh TU; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar-243122, UP, India.
Reprod Toxicol ; 126: 108607, 2024 06.
Article en En | MEDLINE | ID: mdl-38734317
ABSTRACT
Ethion is a class II moderately toxic organothiophosphate pesticide. The main objective of this study was to evaluate the maternal and foetal toxicity of ethion in rats. Pregnant rats were divided into 5 groups. Group I served as control. Group II, III, IV, and V were orally administered with 0.86, 1.71, 3.43, and 6.9 mg/kg of ethion respectively, from gestational day (GD) 6-19. Dams were sacrificed on GD 20. Maternal toxicity was assessed by body weight gain, foetal resorptions, oxidative stress, liver and kidney function tests, and histopathology. Foetal toxicity was assessed by physical status, gross, teratological and histopathological examination. Ethion caused dose-dependent reduction in maternal body weight gain, increased resorptions, and reduced gravid uterine weights. Elevated MDA levels and altered levels of GSH, SOD and catalase were recorded in pregnant dam serum and tissues. SGOT, SGPT, total bilirubin, urea, uric acid, and creatinine were elevated in ethion groups indicating liver and kidney toxicity. Histology of uterus revealed myometrial degeneration and mucosal gland atrophy in uterus of pregnant dams and degenerative changes in placenta. It showed histological alterations in liver, kidney, and lungs. There was reduction in the foetal body weights and placental weights, and degenerative changes in the foetal liver and kidney. Gross evaluation of foetuses showed subcutaneous hematoma. Skeletal evaluation showed partial ossification of skull bones, costal separation, and agenesis of tail vertebrae, sternebrae, metacarpals and metatarsals. The findings reveal that prenatal exposure to ethion caused maternal and foetal toxicity in rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Riñón / Hígado Límite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Riñón / Hígado Límite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Asunto de la revista: EMBRIOLOGIA / MEDICINA REPRODUTIVA / TOXICOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos