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A comparative study of urinary levels of multiple metals and neurotransmitter correlations between GDM and T2DM populations.
Yu, Jia; Wang, Caimei; Liu, Yun; Tao, Tao; Yang, Liuxue; Liu, Ruxi; Liang, Dan; Zhang, Ying; He, Zhuohong; Sun, Yi.
Afiliación
  • Yu J; Department of Toxicology, Guilin Medical University, Guilin 541004, China.
  • Wang C; Department of Laboratory Medicine, Affiliated Hospital of Guilin medical University, Guilin, China.
  • Liu Y; Department of Gynaecolog, Tangshan Central Hospital, Tangshan, Hebei 063000, China.
  • Tao T; Department of Toxicology, Guilin Medical University, Guilin 541004, China.
  • Yang L; Department of Endocrinology, The Second Affiliated Hospital of Guilin Medical College, China.
  • Liu R; Department of Toxicology, Guilin Medical University, Guilin 541004, China.
  • Liang D; Department of Toxicology, Guilin Medical University, Guilin 541004, China.
  • Zhang Y; Department of Toxicology, Guilin Medical University, Guilin 541004, China.
  • He Z; Department of Toxicology, Guilin Medical University, Guilin 541004, China.
  • Sun Y; Department of Toxicology, Guilin Medical University, Guilin 541004, China. Electronic address: sunyide163@163.com.
J Trace Elem Med Biol ; 84: 127447, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38733832
ABSTRACT

OBJECTIVE:

The pathogenesis of GDM and T2DM are closely related to various metals in vivo, and changes in the concentration of these metal exposures can lead to neuropathy through the DNA damage pathway caused by the accumulation of ROS.

METHOD:

Urine samples were analyzed for heavy metals and trace elements by ICP-MS, neurotransmitter metabolites by HPLC, 8-OH-dG by HPLC-MS and metabolomics by UPLC-MS.

RESULT:

Cd and Hg were risk factors for T2DM. There was a positive correlation between 8-OH-dG and neurotransmitter metabolites in both two populations. For GDM, the metabolite with the largest down-regulation effect was desloratadine and the largest up-regulation effect was D-glycine. That tyrosine and carbon metabolites were upregulated in the GDM population and downregulated in the T2DM population.

CONCLUSION:

The BMI, urinary Cd and Hg endo-exposure levels correlated with elevated blood glucose, and the latter may cause changes in the DNA damage marker 8-OH-dG in both study populations and trigger common responses to neurological alterations changes in the neurotransmitter. Tyrosine, carbonin metabolites, alanine, aspartate, and glutamate were signature metabolites that were altered in both study populations. These indicators and markers have clinical implications for monitoring and prevention of neurological injury in patients with GDM and T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurotransmisores Límite: Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: J Trace Elem Med Biol Asunto de la revista: METABOLISMO / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neurotransmisores Límite: Adult / Female / Humans / Middle aged / Pregnancy Idioma: En Revista: J Trace Elem Med Biol Asunto de la revista: METABOLISMO / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article Pais de publicación: Alemania