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Vasoactive intestinal peptide exerts an osteoinductive effect in human mesenchymal stem cells.
Castro-Vázquez, David; Arribas-Castaño, Paula; García-López, Iván; Gutiérrez-Cañas, Irene; Pérez-García, Selene; Lamana, Amalia; Villanueva-Romero, Raúl; Cabrera-Martín, Alicia; Tecza, Karolina; Martínez, Carmen; Juarranz, Yasmina; Gomariz, Rosa P; Carrión, Mar.
Afiliación
  • Castro-Vázquez D; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Arribas-Castaño P; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • García-López I; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Gutiérrez-Cañas I; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Pérez-García S; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Lamana A; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Villanueva-Romero R; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Cabrera-Martín A; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Tecza K; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Martínez C; Departmental Section of Cell Biology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.
  • Juarranz Y; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Gomariz RP; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
  • Carrión M; Department of Cell Biology, Faculty of Biological Science, Complutense University of Madrid, Madrid, Spain.
Biofactors ; 2024 May 11.
Article en En | MEDLINE | ID: mdl-38733572
ABSTRACT
Several neuropeptides present in bone tissues, produced by nerve fibers and bone cells, have been reported to play a role in regulating the fine-tuning of osteoblast and osteoclast functions to maintain bone homeostasis. This study aims to characterize the influence of the neuropeptide vasoactive intestinal peptide (VIP) on the differentiation process of human mesenchymal stem cells (MSCs) into osteoblasts and on their anabolic function. We describe the mRNA and protein expression profile of VIP and its receptors in MSCs as they differentiate into osteoblasts, suggesting the presence of an autocrine signaling pathway in these cells. Our findings reveal that VIP enhances the expression of early osteoblast markers in MSCs under osteogenic differentiation and favors both bone matrix formation and proper cytoskeletal reorganization. Finally, our data suggest that VIP could be exerting a direct modulatory role on the osteoblast to osteoclast signaling by downregulating the receptor activator of nuclear factor-κB ligand/osteoprotegerin ratio. These results highlight the potential of VIP as an osteoinductive differentiation factor, emerging as a key molecule in the maintenance of human bone homeostasis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biofactors Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biofactors Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Países Bajos