Immunocompetence of chimeric rabbits. III. Serial passage and persistence of B-lymphocyte memory.
Cell Immunol
; 91(2): 385-96, 1985 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-3873281
In a model consisting of noninbred rabbits matched for major histocompatibility antigens and mismatched for immunoglobulin allotypes, using cell donors and recipients unrelated to each other, B-cell memory has been demonstrated to persist through three successive transfers for a period approaching 2 years. Memory cells from the original donor are shown to dominate specific antibody responses of the primary and secondary recipients. Vigorous antibody responses by donor-derived cells are obtained even when antigenic stimulation is delayed by several months. The data suggest that B memory cells may be particularly efficient in the colonization of recipients, and the potential significance of these findings for adoptive immunization of human bone marrow recipients is discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Quimera
/
Memoria Inmunológica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cell Immunol
Año:
1985
Tipo del documento:
Article
Pais de publicación:
Países Bajos