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The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Sinopoli, Alessandra; Sciurti, Antonio; Isonne, Claudia; Santoro, Maria Mercedes; Baccolini, Valentina.
Afiliación
  • Sinopoli A; Local Health Authority Roma 1, Department of Prevention, 00193 Rome, Italy.
  • Sciurti A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Isonne C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  • Santoro MM; Department of Experimental Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
  • Baccolini V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
Nutrients ; 16(9)2024 Apr 29.
Article en En | MEDLINE | ID: mdl-38732592
ABSTRACT
This review aims to evaluate the efficacy of any vitamin administration(s) in preventing and managing COVID-19 and/or long-COVID. Databases were searched up to May 2023 to identify randomized clinical trials comparing data on the effects of vitamin supplementation(s) versus placebo or standard of care on the two conditions of interest. Inverse-variance random-effects meta-analyses were conducted to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs) for all-cause mortality between supplemented and non-supplemented individuals. Overall, 37 articles were included two regarded COVID-19 and long-COVID prevention and 35 records the COVID-19 management. The effects of vitamin D in preventing COVID-19 and long-COVID were contrasting. Similarly, no conclusion could be drawn on the efficacy of multivitamins, vitamin A, and vitamin B in COVID-19 management. A few positive findings were reported in some vitamin C trials but results were inconsistent in most outcomes, excluding all-cause mortality (RR = 0.84; 95% CI 0.72-0.97). Vitamin D results were mixed in most aspects, including mortality, in which benefits were observed in regular administrations only (RR = 0.67; 95% CI 0.49-0.91). Despite some benefits, results were mostly contradictory. Variety in recruitment and treatment protocols might explain this heterogeneity. Better-designed studies are needed to clarify these vitamins' potential effects against SARS-CoV-2.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Vitamina A / Vitamina D / Vitaminas / Ensayos Clínicos Controlados Aleatorios como Asunto / Suplementos Dietéticos / SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Ascórbico / Vitamina A / Vitamina D / Vitaminas / Ensayos Clínicos Controlados Aleatorios como Asunto / Suplementos Dietéticos / SARS-CoV-2 / COVID-19 Límite: Humans Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza