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Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial.
Mantri, Aakash; Köhlmoos, Anika; Schelski, Daniela Stephanie; Seel, Waldemar; Stoffel-Wagner, Birgit; Krawitz, Peter; Stehle, Peter; Holst, Jens Juul; Weber, Bernd; Koban, Leonie; Plassmann, Hilke; Simon, Marie-Christine.
Afiliación
  • Mantri A; Institute of Nutrition and Food Science, Nutrition and Microbiota, University of Bonn, 53115 Bonn, Germany.
  • Köhlmoos A; Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, 53127 Bonn, Germany.
  • Schelski DS; Institute of Nutrition and Food Science, Nutrition and Microbiota, University of Bonn, 53115 Bonn, Germany.
  • Seel W; Center for Economics and Neuroscience, University of Bonn, 53113 Bonn, Germany.
  • Stoffel-Wagner B; Institute of Experimental Epileptology and Cognition Research, University of Bonn, 53113 Bonn, Germany.
  • Krawitz P; Institute of Nutrition and Food Science, Nutrition and Microbiota, University of Bonn, 53115 Bonn, Germany.
  • Stehle P; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, 53127 Bonn, Germany.
  • Holst JJ; Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, 53127 Bonn, Germany.
  • Weber B; Institute of Nutrition and Food Science, Nutritional Physiology, University of Bonn, 53115 Bonn, Germany.
  • Koban L; Novo Nordisk Foundation Center for Basic Metabolic Research, Department for Biomedical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
  • Plassmann H; Center for Economics and Neuroscience, University of Bonn, 53113 Bonn, Germany.
  • Simon MC; Institute of Experimental Epileptology and Cognition Research, University of Bonn, 53113 Bonn, Germany.
Nutrients ; 16(9)2024 Apr 26.
Article en En | MEDLINE | ID: mdl-38732547
ABSTRACT
Synbiotics modulate the gut microbiome and contribute to the prevention of liver diseases such as metabolic-dysfunction-associated fatty liver disease (MAFLD). This study aimed to evaluate the effect of a randomized, placebo-controlled, double-blinded seven-week intervention trial on the liver metabolism in 117 metabolically healthy male participants. Anthropometric data, blood parameters, and stool samples were analyzed using linear mixed models. After seven weeks of intervention, there was a significant reduction in alanine aminotransferase (ALT) in the synbiotic group compared to the placebo group (-14.92%, CI -26.60--3.23%, p = 0.013). A stratified analysis according to body fat percentage revealed a significant decrease in ALT (-20.70%, CI -40.88--0.53%, p = 0.045) in participants with an elevated body fat percentage. Further, a significant change in microbiome composition (1.16, CI 0.06-2.25, p = 0.039) in this group was found, while the microbial composition remained stable upon intervention in the group with physiological body fat. The 7-week synbiotic intervention reduced ALT levels, especially in participants with an elevated body fat percentage, possibly due to modulation of the gut microbiome. Synbiotic intake may be helpful in delaying the progression of MAFLD and could be used in addition to the recommended lifestyle modification therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alanina Transaminasa / Simbióticos / Microbioma Gastrointestinal / Hígado Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Alanina Transaminasa / Simbióticos / Microbioma Gastrointestinal / Hígado Límite: Adult / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza