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Inhibition of Prostate Cancer Cell Survival and Proliferation by Carnosic Acid Is Associated with Inhibition of Akt and Activation of AMPK Signaling.
Nadile, Matteo; Sze, Newman Siu Kwan; Fajardo, Val A; Tsiani, Evangelia.
Afiliación
  • Nadile M; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Sze NSK; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Fajardo VA; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
  • Tsiani E; Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada.
Nutrients ; 16(9)2024 Apr 24.
Article en En | MEDLINE | ID: mdl-38732504
ABSTRACT
Prostate cancer, accounting for 375,304 deaths in 2020, is the second most prevalent cancer in men worldwide. While many treatments exist for prostate cancer, novel therapeutic agents with higher efficacy are needed to target aggressive and hormone-resistant forms of prostate cancer, while sparing healthy cells. Plant-derived chemotherapy drugs such as docetaxel and paclitaxel have been established to treat cancers including prostate cancer. Carnosic acid (CA), a phenolic diterpene found in the herb rosemary (Rosmarinus officinalis) has been shown to have anticancer properties but its effects in prostate cancer and its mechanisms of action have not been examined. CA dose-dependently inhibited PC-3 and LNCaP prostate cancer cell survival and proliferation (IC50 64, 21 µM, respectively). Furthermore, CA decreased phosphorylation/activation of Akt, mTOR, and p70 S6K. A notable increase in phosphorylation/activation of AMP-activated kinase (AMPK), acetyl-CoA carboxylase (ACC) and its upstream regulator sestrin-2 was seen with CA treatment. Our data indicate that CA inhibits AKT-mTORC1-p70S6K and activates Sestrin-2-AMPK signaling leading to a decrease in survival and proliferation. The use of inhibitors and small RNA interference (siRNA) approaches should be employed, in future studies, to elucidate the mechanisms involved in carnosic acid's inhibitory effects of prostate cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Transducción de Señal / Supervivencia Celular / Abietanos / Proliferación Celular / Proteínas Proto-Oncogénicas c-akt / Proteínas Quinasas Activadas por AMP Límite: Humans / Male Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Transducción de Señal / Supervivencia Celular / Abietanos / Proliferación Celular / Proteínas Proto-Oncogénicas c-akt / Proteínas Quinasas Activadas por AMP Límite: Humans / Male Idioma: En Revista: Nutrients Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza