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Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives.
Jankovská, Dagmar; Jurcová, Nikol; Kubínová, Renata; Václavík, Jirí; Svajdlenka, Emil; Mascellani, Anna; Marsík, Petr; Bouzková, Katerina; Malaník, Milan.
Afiliación
  • Jankovská D; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého trída 1946/1, 61200 Brno, Czech Republic.
  • Jurcová N; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého trída 1946/1, 61200 Brno, Czech Republic.
  • Kubínová R; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého trída 1946/1, 61200 Brno, Czech Republic.
  • Václavík J; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého trída 1946/1, 61200 Brno, Czech Republic.
  • Svajdlenka E; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého trída 1946/1, 61200 Brno, Czech Republic.
  • Mascellani A; Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 16500 Prague, Czech Republic.
  • Marsík P; Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 16500 Prague, Czech Republic.
  • Bouzková K; Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 5/C04, 62500 Brno, Czech Republic.
  • Malaník M; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackého trída 1946/1, 61200 Brno, Czech Republic.
Plants (Basel) ; 13(9)2024 Apr 24.
Article en En | MEDLINE | ID: mdl-38732396
ABSTRACT
Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 ± 1.9% for AChE and 90.0 ± 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Plants (Basel) Año: 2024 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Plants (Basel) Año: 2024 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Suiza