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Circulating Blood Prognostic Biomarker Signatures for Hemorrhagic Cerebral Cavernous Malformations (CCMs).
Croft, Jacob; Grajeda, Brian; Aguirre, Luis A; Abou-Fadel, Johnathan S; Ellis, Cameron C; Estevao, Igor; Almeida, Igor C; Zhang, Jun.
Afiliación
  • Croft J; Department of Molecular and Translational Medicine, Texas Tech University Health Science Center El Paso (TTUHSCEP), El Paso, TX 79905, USA.
  • Grajeda B; Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79902, USA.
  • Aguirre LA; Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79902, USA.
  • Abou-Fadel JS; Department of Molecular and Translational Medicine, Texas Tech University Health Science Center El Paso (TTUHSCEP), El Paso, TX 79905, USA.
  • Ellis CC; Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79902, USA.
  • Estevao I; Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79902, USA.
  • Almeida IC; Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79902, USA.
  • Zhang J; Department of Molecular and Translational Medicine, Texas Tech University Health Science Center El Paso (TTUHSCEP), El Paso, TX 79905, USA.
Int J Mol Sci ; 25(9)2024 Apr 26.
Article en En | MEDLINE | ID: mdl-38731959
ABSTRACT
Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by enlarged intracranial capillaries in the brain, increasing the susceptibility to hemorrhagic strokes, a major cause of death and disability worldwide. The limited treatment options for CCMs underscore the importance of prognostic biomarkers to predict the likelihood of hemorrhagic events, aiding in treatment decisions and identifying potential pharmacological targets. This study aimed to identify blood biomarkers capable of diagnosing and predicting the risk of hemorrhage in CCM1 patients, establishing an initial set of circulating biomarker signatures. By analyzing proteomic profiles from both human and mouse CCM models and conducting pathway enrichment analyses, we compared groups to identify potential blood biomarkers with statistical significance. Specific candidate biomarkers primarily associated with metabolism and blood clotting pathways were identified. These biomarkers show promise as prognostic indicators for CCM1 deficiency and the risk of hemorrhagic stroke, strongly correlating with the likelihood of hemorrhagic cerebral cavernous malformations (CCMs). This lays the groundwork for further investigation into blood biomarkers to assess the risk of hemorrhagic CCMs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Hemangioma Cavernoso del Sistema Nervioso Central Límite: Animals / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Hemangioma Cavernoso del Sistema Nervioso Central Límite: Animals / Female / Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza