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Fused in sarcoma (FUS) inhibits milk production efficiency in mammals.
Shao, Haili; Huang, Jipeng; Wang, Hui; Wang, Guolei; Yang, Xu; Cheng, Mei; Sun, Changjie; Zou, Li; Yang, Qin; Zhang, Dandan; Liu, Zhen; Jiang, Xuelong; Shi, Lei; Shi, Peng; Han, Baowei; Jiao, Baowei.
Afiliación
  • Shao H; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Huang J; Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Wang H; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Wang G; Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Yang X; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Cheng M; Department of Obstetrics, Weifang People's Hospital, Weifang, Shandong, 261042, China.
  • Sun C; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Zou L; Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Yang Q; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Zhang D; Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Liu Z; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Jiang X; Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Shi L; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Shi P; Kunming College of Life Science, University of the Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Han B; National Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650201, China.
  • Jiao B; Luoyang Maternal and Child Health Hospital, Luoyang, Henan, 471000, China.
Nat Commun ; 15(1): 3953, 2024 May 10.
Article en En | MEDLINE | ID: mdl-38729967
ABSTRACT
Efficient milk production in mammals confers evolutionary advantages by facilitating the transmission of energy from mother to offspring. However, the regulatory mechanism responsible for the gradual establishment of milk production efficiency in mammals, from marsupials to eutherians, remains elusive. Here, we find that mammary gland of the marsupial sugar glider contained milk components during adolescence, and that mammary gland development is less dynamically cyclic compared to that in placental mammals. Furthermore, fused in sarcoma (FUS) is found to be partially responsible for this establishment of low efficiency. In mouse model, FUS inhibit mammary epithelial cell differentiation through the cyclin-dependent kinase inhibitor p57Kip2, leading to lactation failure and pup starvation. Clinically, FUS levels are negatively correlated with milk production in lactating women. Overall, our results shed light on FUS as a negative regulator of milk production, providing a potential mechanism for the establishment of milk production from marsupial to eutherian mammals.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia / Macropodidae / Glándulas Mamarias Animales Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia / Macropodidae / Glándulas Mamarias Animales Límite: Animals / Female / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido