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Urinary Ferritin as a Noninvasive Means of Assessing Iron Status in Young Children.
Moumin, Najma A; D'Vaz, Nina; Kidd, Courtney; MacRae, Andrea; Zhou, Shao J; Richards, Toby; Palmer, Debra J; Grzeskowiak, Luke E; Sullivan, Thomas R; Green, Tim J.
Afiliación
  • Moumin NA; Women and Kids Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Discipline of Pediatrics, Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address: najma.m
  • D'Vaz N; Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia; School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
  • Kidd C; Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
  • MacRae A; Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia.
  • Zhou SJ; School of Agriculture, Food & Wine, The University of Adelaide, Urrbrae, South Australia, Australia; Robinson Research Institute, The University of Adelaide, Adelaide, South Australia, Australia.
  • Richards T; School of Medicine, Division of Surgery, University of Western Australia, Perth, Western Australia, Australia.
  • Palmer DJ; Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia; School of Medicine, University of Western Australia, Crawley, Western Australia, Australia.
  • Grzeskowiak LE; Women and Kids Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
  • Sullivan TR; Women and Kids Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; Discipline of Public Health, Faculty of Health and Medical Sciences, Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
  • Green TJ; Women and Kids Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia; College of Nursing and Health Sciences, Flinders University, Bedford Park, South Australia, Australia.
J Nutr ; 154(9): 2688-2695, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38729575
ABSTRACT

BACKGROUND:

Iron deficiency (ID) is the most common nutritional deficiency affecting young children. Serum ferritin concentration is the preferred biomarker for measuring iron status because it reflects iron stores; however, blood collection can be distressing for young children and can be logistically difficult. A noninvasive means to measure iron status would be attractive to either diagnose or screen for ID in young children.

OBJECTIVES:

This study aimed to determine the correlation between urinary and serum ferritin concentrations in young children; to determine whether correcting urinary ferritin for creatinine and specific gravity improves the correlation; and to determine a urine ferritin cut point to predict ID.

METHODS:

Validation study was conducted using paired serum and urine collected from 3-y-old children (n = 142) participating in a longitudinal birth cohort study the ORIGINS project in Perth, Western Australia. We calculated the sensitivity, specificity, positive, and negative predictive values of urinary ferritin amount in identifying those with ID at the clinical cut point used by the World Health Organization (serum ferritin concentration of <12 ng/mL).

RESULTS:

Urine ferritin, corrected for creatinine, correlated moderately with serum ferritin [r = 0.53 (0.40-0.64)] and performed well in predicting those with ID (area under the curve 0.85; 95% confidence interval 0.75, 0.94). Urine ferritin <2.28 ng/mg creatinine was sensitive (86%) and specific (77%) in predicting ID and had a high negative predictive value of 97%; however, the positive predictive value was low (40%) owing to the low prevalence of ID in the sample (16%).

CONCLUSIONS:

Urine ferritin shows good diagnostic performance for ID. This noninvasive biomarker maybe a useful screening tool to exclude ID in healthy young children; however, further research is needed in other populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Estado Nutricional / Anemia Ferropénica / Creatinina / Ferritinas / Hierro Límite: Child, preschool / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: J Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Estado Nutricional / Anemia Ferropénica / Creatinina / Ferritinas / Hierro Límite: Child, preschool / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: J Nutr Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos