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Characteristic cembrane-type diterpenoids with nitric oxide inhibitory activity from the gum resin of Boswellia carterii Birdw.
Xu, Lian-Lian; Chen, Zhi-Chao; He, Meng-Li; Fu, Jian-Jiang; Li, Yang; Luo, Yong-Ming; Chen, Fang-You.
Afiliación
  • Xu LL; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China.
  • Chen ZC; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China.
  • He ML; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China.
  • Fu JJ; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China.
  • Li Y; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China.
  • Luo YM; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China. Electronic address: loym999@163.com.
  • Chen FY; School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, People's Republic of China. Electronic address: chenfy2018@jxutcm.edu.cn.
Fitoterapia ; 176: 106000, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38729248
ABSTRACT
Five new characteristic cembrane-type diterpenoids (olibacartiols A-E, 1-5) were acquired from the gum resin of Boswellia carterii. The structures of these diterpenoids were characterized by detailed spectroscopic analysis, and compounds 1-3 were unambiguously confirmed by single-crystal X-ray diffraction experiments. The anti-inflammatory activities of the isolated compounds were evaluated using LPS-induced BV2 cell model and compounds 2-5 showed moderate NO inhibitory effects with IC50 values of 8.84 ± 1.02, 9.82 ± 1.95, 9.75 ± 2.24, and 7.39 ± 1.24 µM, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas de Plantas / Boswellia / Diterpenos / Fitoquímicos / Antiinflamatorios / Óxido Nítrico Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Resinas de Plantas / Boswellia / Diterpenos / Fitoquímicos / Antiinflamatorios / Óxido Nítrico Límite: Animals País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos