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Comparative analysis of liver resection in Non-B Non-C and hepatitis virus-associated hepatocellular carcinoma.
Takamoto, Takeshi; Nara, Satoshi; Ban, Daisuke; Mizui, Takahiro; Mukai, Masami; Minoru, Esaki; Shimada, Kazuaki.
Afiliación
  • Takamoto T; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan. Electronic address: ttakamot@ncc.go.jp.
  • Nara S; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Ban D; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Mizui T; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Mukai M; Department of Medical Informatics, National Cancer Center Hospital, Japan.
  • Minoru E; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.
  • Shimada K; Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan.
Eur J Surg Oncol ; 50(7): 108381, 2024 Jul.
Article en En | MEDLINE | ID: mdl-38728963
ABSTRACT

BACKGROUND:

The incidence of non-hepatitis B and non-hepatitis C hepatocellular carcinoma (NBNC-HCC) is increasing in our country. This study assesses the feasibility of employing an identical surgical treatment strategy for resectable NBNC-HCC as that for hepatitis virus-associated HCC (HV-HCC).

METHODS:

A retrospective analysis (1993-2023) of 1321 curative liver resections for HCC at a single institution was performed. Propensity score matching ensured a balanced comparison of preoperative clinical factors, including tumor status and background liver condition.

RESULTS:

The proportion of NBNC-HCC cases has gradually increased, reaching up to 70 %. After matching, 294 of 473 NBNC-HCC patients and 294 of 848 HV-HCC patients were compared. Operative outcomes, including operation time, blood loss, type of surgical procedure, and morbidity, were comparable. Long-term outcome analysis showed similar recurrence-free survival (HR 0.86, 95 % CI 0.70-1.06, P = 0.167) and overall survival (HR 0.98, 95 % CI 0.79-1.23, P = 0.865) for NBNC-HCC. Multivariable analysis identified ICGR15 ≥ 15 %, ALBI grade 2 or 3, aspartate aminotransferase ≥40, tumor size > 5 cm, multiple tumors, macrovascular invasion, and microvascular invasion as independent prognostic factors for overall survival, while hepatitis B or C virus status lost significance.

CONCLUSIONS:

Despite the increasing incidence of NBNC-HCC, comparable outcomes were achieved between the two groups of matched cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Puntaje de Propensión / Hepatectomía / Neoplasias Hepáticas Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Puntaje de Propensión / Hepatectomía / Neoplasias Hepáticas Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Surg Oncol Asunto de la revista: NEOPLASIAS Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido