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Assessing microplastics-antibiotics coexistence induced ciprofloxacin-resistant Pseudomonas aeruginosa at a water region scale.
Wang, Wei-Min; Lu, Tien-Hsuan; Chen, Chi-Yun; Liao, Chung-Min.
Afiliación
  • Wang WM; Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 106319, China.
  • Lu TH; Department of Science Education and Application, National Taichung University of Education, Taichung 403514, China.
  • Chen CY; Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610, United States; Center for Environmental and Human Toxicology, University of Florida, FL 32608, United States.
  • Liao CM; Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei, Taiwan 106319, China. Electronic address: cmliao@ntu.edu.tw.
Water Res ; 257: 121721, 2024 Jun 15.
Article en En | MEDLINE | ID: mdl-38728782
ABSTRACT
Microplastics (MPs) waste is widespread globally in water systems. The opportunistic human pathogen Pseudomonas aeruginosa can cause serious acute and chronic infections that are notoriously difficult to treat. Ciprofloxacin (CIP) is broadly applied as an anti-P. aeruginosa drug. A growing evidence reveals that antibiotic-resistance genes-carrying Pseudomonas aeruginosa were detected on MPs forming plastisphere due to their adsorbability along with high occurrence of CIP in water environments. The MPs-niched CIP-resistant P. aeruginosa has been likely to emerge as an unignorable public health issue. Here, we offered a novel approach to assess the development of CIP-resistant P. aeruginosa under MPs-antibiotic coexistence at a water region scale. By combing the adsorption isotherm models used to estimate CIP condensation around MPs and a pharmacokinetic/pharmacodynamic-based microbial population dynamic model, we predicted the P. aeruginosa development on CIP-adsorbed MPs in waters. Our assessment revealed a high antibiotic resistance in the P. aeruginosa populations (∼50 %) with a wider range of waterborne total cell counts (∼10-2-104 cfu mL-1) among water regions in that the resistance proportion was primarily determined by CIP pollution level and relative abundance of various polymer type of MPs. We implicate that water region-specific MPs were highly likely to provide media for P. aeruginosa propagation. Our results highlight the importance of antibiotic-resistant pathogen colonization-emerging environmental medium interactions when addressing global threat from MPs pollution, in the context of MPs-antibiotics co-contamination assessment and for the continued provision of water system management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Ciprofloxacina / Microplásticos / Antibacterianos Idioma: En Revista: Water Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Ciprofloxacina / Microplásticos / Antibacterianos Idioma: En Revista: Water Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido