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Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia.
Yuba, Tomoo; Koyama, Yoshihisa; Kinishi, Yuki; Uokawa, Reiko; Ootaki, Chiyo; Shimada, Shoichi; Fujino, Yuji.
Afiliación
  • Yuba T; Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. yottuno8hatomoo@gmail.com.
  • Koyama Y; Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. yottuno8hatomoo@gmail.com.
  • Kinishi Y; Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. koyama@anat2.med.osaka-u.ac.jp.
  • Uokawa R; Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, 541-8567, Japan. koyama@anat2.med.osaka-u.ac.jp.
  • Ootaki C; Global Center for Medical Engineering and Informatics, Osaka University, Suita, 565-0871, Japan. koyama@anat2.med.osaka-u.ac.jp.
  • Shimada S; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, 565-0871, Japan. koyama@anat2.med.osaka-u.ac.jp.
  • Fujino Y; Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Reprod Sci ; 31(9): 2753-2762, 2024 09.
Article en En | MEDLINE | ID: mdl-38727999
ABSTRACT
Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, we focused on oxidative stress during delivery and conducted a cross-sectional analysis of maternal and fetal oxidative stress. The participants included 15 women who received LEA (LEA group) and 15 who did not (No LEA group). Participants with a gestational age of < 37 weeks, BMI of ≥ 35 kg/m2, cerebrovascular or cardiovascular complications, multiple pregnancies, gestational hypertension, gestational diabetes, chronic hypertension, thyroid disease, birth weight of < 2,500 g, emergency cesarean section, or cases in which epidural anesthesia was re-administered during delivery were excluded from the study. Maternal blood was collected on admission, and immediately after delivery, and umbilical artery blood was collected from the fetus. The oxidative stress status was assessed by measuring diacron-reactive oxygen metabolite (an index of the degree of lipid peroxide oxidation), biological antioxidant potential (an index of antioxidant capacity) and calculating the ratio of BAP/d-ROMs (an index of the oxidative stress). The results showed that maternal oxidative stress immediately after delivery was lower in the LEA group than in the No LEA group. Moreover, the fetuses experienced less oxidative stress in the LEA group than in the No LEA group. Taken together, these results suggest that LEA may reduce maternal and fetal oxidative stress associated with childbirth.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Analgesia Epidural / Estrés Oxidativo Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Analgesia Epidural / Estrés Oxidativo Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Reprod Sci Asunto de la revista: MEDICINA REPRODUTIVA Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos