Your browser doesn't support javascript.
loading
Berberine attenuates brain aging via stabilizing redox homeostasis and inflammation in an accelerated senescence model of Wistar rats.
Yadawa, Arun Kumar; Srivastava, Parisha; Singh, Akanksha; Kumar, Raushan; Arya, Jitendra Kumar; Rizvi, Syed Ibrahim.
Afiliación
  • Yadawa AK; Department of Biochemistry, University of Allahabad, 211002, Allahabad, India.
  • Srivastava P; Department of Biochemistry, University of Allahabad, 211002, Allahabad, India.
  • Singh A; Department of Biochemistry, University of Allahabad, 211002, Allahabad, India.
  • Kumar R; Department of Biochemistry, University of Allahabad, 211002, Allahabad, India.
  • Arya JK; Department of Biochemistry, University of Allahabad, 211002, Allahabad, India.
  • Rizvi SI; Department of Biochemistry, University of Allahabad, 211002, Allahabad, India. sirizvi@gmail.com.
Metab Brain Dis ; 39(5): 649-659, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38727934
ABSTRACT
Aging is a multifaceted and progressive physiological change of the organism categorized by the accumulation of deteriorating processes, which ultimately compromise the biological functions. The objective of this study was to investigate the anti-aging potential of berberine (BBR) in D-galactose (D-Gal) induced aging in rat models. In this study, male Wistar rats were divided into four groups The control group was given only vehicle, the BBR group was treated with berberine orally, the D-Gal group was treated with D-galactose subcutaneously and the BBR + D-Gal group was treated with D-galactose and berberine simultaneously. D-galactose exposure elevated the pro-oxidants such as malondialdehyde (MDA) level, protein carbonyl and advanced oxidation protein products (AOPP) in the brain. It decreased the anti-oxidants such as reduced glutathione (GSH) and ferric reducing antioxidant potential (FRAP) in the brain. D-galactose treatment also reduced the mitochondrial complexes (I, II, III and IV) activities and elevated the inflammatory markers such as interleukine-6 (IL-6), tumor necrosis factor- α (TNF-α) and C-reactive protein (CRP). The mRNA expressions of IL-6 and TNF-α in the brain were upregulated following D-galactose exposure. Berberine co-treatment in D-galactose induced aging rat model prevented the alteration of pro-oxidant and anti-oxidant in the brain. Berberine treatment restored the mitochondrial complex activities in the brain and also normalized the inflammatory markers. Based on these findings we conclude that berberine treatment has the potential to mitigate brain aging in rats via stabilizing the redox equilibrium and neuroinflammation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Berberina / Encéfalo / Envejecimiento / Ratas Wistar / Estrés Oxidativo / Galactosa Límite: Animals Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Berberina / Encéfalo / Envejecimiento / Ratas Wistar / Estrés Oxidativo / Galactosa Límite: Animals Idioma: En Revista: Metab Brain Dis Asunto de la revista: CEREBRO / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos