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CLIC4 Function in the Epithelial-Mesenchymal Transition of Epithelial Odontogenic Lesions.
Xerez, Mariana Carvalho; da Silva Barros, Caio César; de Souto Medeiros, Maurília Raquel; Mafra, Rodrigo Porpino; de Lucena, Hévio Freitas; da Silveira, Éricka Janine Dantas; de Lisboa Lopes Costa, Antonio.
Afiliación
  • Xerez MC; Oral Pathology and Medicine, Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil. m.carvalhoxerez@gmail.com.
  • da Silva Barros CC; Oral Pathology and Medicine, Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • de Souto Medeiros MR; Oral Pathology and Medicine, Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Mafra RP; Oral Pathology and Medicine, Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • de Lucena HF; Department of Dentistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 1787, Lagoa Nova, Natal, CEP: 59056-000, RN, Brazil.
  • da Silveira ÉJD; Oral Pathology and Medicine, Postgraduate Program in Dental Sciences, Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • de Lisboa Lopes Costa A; Department of Dentistry, Federal University of Rio Grande do Norte, Av. Salgado Filho, 1787, Lagoa Nova, Natal, CEP: 59056-000, RN, Brazil.
Head Neck Pathol ; 18(1): 40, 2024 May 10.
Article en En | MEDLINE | ID: mdl-38727794
ABSTRACT

BACKGROUND:

Odontogenic lesions constitute a heterogeneous group of lesions. CLIC4 protein regulates different cellular processes, including epithelial-mesenchymal transition and fibroblast-myofibroblast transdifferentiation. This study analyzed CLIC4, E-cadherin, Vimentin, and α-SMA immunoexpression in epithelial odontogenic lesions that exhibit different biological behavior.

METHODS:

It analyzed the immunoexpression of CLIC4, E-cadherin, and Vimentin in the epithelial cells, as well as CLIC4 and α-SMA in the mesenchymal cells, of ameloblastoma (AM) (n = 16), odontogenic keratocyst (OKC) (n = 20), and adenomatoid odontogenic tumor (AOT) (n = 8). Immunoexpressions were categorized as score 0 (0% positive cells), 1 (< 25%), 2 (≥ 25% - < 50%), 3 (≥ 50% - < 75%), or 4 (≥ 75%).

RESULTS:

Cytoplasmic CLIC4 immunoexpression was higher in AM and AOT (p < 0.001) epithelial cells. Nuclear-cytoplasmic CLIC4 was higher in OKC's epithelial lining (p < 0.001). Membrane (p = 0.012) and membrane-cytoplasmic (p < 0.001) E-cadherin immunoexpression were higher in OKC, while cytoplasmic E-cadherin expression was higher in AM and AOT (p < 0.001). Vimentin immunoexpression was higher in AM and AOT (p < 0.001). Stromal CLIC4 was higher in AM and OKC (p = 0.008). Similarly, α-SMA immunoexpression was higher in AM and OKC (p = 0.037). Correlations in these proteins' immunoexpression were observed in AM and OKC (p < 0.05).

CONCLUSIONS:

CLIC4 seems to regulate the epithelial-mesenchymal transition, modifying E-cadherin and Vimentin expression. In mesenchymal cells, CLIC4 may play a role in fibroblast-myofibroblast transdifferentiation. CLIC4 may be associated with epithelial odontogenic lesions with aggressive biological behavior.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vimentina / Ameloblastoma / Tumores Odontogénicos / Cadherinas / Canales de Cloruro / Transición Epitelial-Mesenquimal Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Pathol Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vimentina / Ameloblastoma / Tumores Odontogénicos / Cadherinas / Canales de Cloruro / Transición Epitelial-Mesenquimal Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Head Neck Pathol Asunto de la revista: NEOPLASIAS / PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos