Mitonuclear interactions impact aerobic metabolism in hybrids and may explain mitonuclear discordance in young, naturally hybridizing bird lineages.

McDiarmid, Callum S; Hooper, Daniel M; Stier, Antoine; Griffith, Simon C

McDiarmid, Callum S; Hooper, Daniel M; Stier, Antoine; Griffith, Simon C.

Afiliación

McDiarmid CS; School of Natural Sciences, Macquarie University, Sydney, New South Wales, Australia.
Hooper DM; Institute for Comparative Genomics and Richard Gilder Graduate School, American Museum of Natural History, New York, New York, USA.
Stier A; Department of Biology, University of Turku, Turku, Finland.
Griffith SC; Institut Pluridisciplinaire Hubert Curien, UMR7178, Université de Strasbourg, CNRS, Strasbourg, France.

Mol Ecol ; 33(12): e17374, 2024 Jun.

Article en En | MEDLINE | ID: mdl-38727686

ABSTRACT

ABSTRACT

Understanding genetic incompatibilities and genetic introgression between incipient species are major goals in evolutionary biology. Mitochondrial genes evolve rapidly and exist in dense gene networks with coevolved nuclear genes, suggesting that mitochondrial respiration may be particularly susceptible to disruption in hybrid organisms. Mitonuclear interactions have been demonstrated to contribute to hybrid dysfunction between deeply divergent taxa crossed in the laboratory, but there are few empirical examples of mitonuclear interactions between younger lineages that naturally hybridize. Here, we use controlled hybrid crosses and high-resolution respirometry to provide the first experimental evidence in a bird that inter-lineage mitonuclear interactions impact mitochondrial aerobic metabolism. Specifically, respiration capacity of the two mitodiscordant backcrosses (with mismatched mitonuclear combinations) differs from one another, although they do not differ significantly from the parental groups or mitoconcordant backcrosses as we would expect of mitonuclear disruptions. In the wild hybrid zone between these subspecies, the mitochondrial cline centre is shifted west of the nuclear cline centre, which is consistent with the direction of our experimental results. Our results therefore demonstrate asymmetric mitonuclear interactions that impact the capacity of cellular mitochondrial respiration and may help to explain the geographic discordance between mitochondrial and nuclear genomes observed in the wild.

Asunto(s)

Hibridación Genética; Animales; Mitocondrias/genética; Mitocondrias/metabolismo; Núcleo Celular/genética; ADN Mitocondrial/genética; Masculino; Aves/genética

Palabras clave

aerobic respiration; cytonuclear discordance; hybridization; mitochondrial; speciation

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hibridación Genética Límite: Animals Idioma: En Revista: Mol Ecol Asunto de la revista: BIOLOGIA MOLECULAR / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

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