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Induced Pluripotent Stem Cells and Organoids in Advancing Neuropathology Research and Therapies.
Pazzin, Douglas Bottega; Previato, Thales Thor Ramos; Budelon Gonçalves, João Ismael; Zanirati, Gabriele; Xavier, Fernando Antonio Costa; da Costa, Jaderson Costa; Marinowic, Daniel Rodrigo.
Afiliación
  • Pazzin DB; Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
  • Previato TTR; Graduate Program in Pediatrics and Child Health, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil.
  • Budelon Gonçalves JI; Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
  • Zanirati G; Graduate Program in Biomedical Gerontology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil.
  • Xavier FAC; Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
  • da Costa JC; Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
  • Marinowic DR; Brain Institute of Rio Grande do Sul (BraIns), Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90610-000, Brazil.
Cells ; 13(9)2024 Apr 25.
Article en En | MEDLINE | ID: mdl-38727281
ABSTRACT
This review delves into the groundbreaking impact of induced pluripotent stem cells (iPSCs) and three-dimensional organoid models in propelling forward neuropathology research. With a focus on neurodegenerative diseases, neuromotor disorders, and related conditions, iPSCs provide a platform for personalized disease modeling, holding significant potential for regenerative therapy and drug discovery. The adaptability of iPSCs, along with associated methodologies, enables the generation of various types of neural cell differentiations and their integration into three-dimensional organoid models, effectively replicating complex tissue structures in vitro. Key advancements in organoid and iPSC generation protocols, alongside the careful selection of donor cell types, are emphasized as critical steps in harnessing these technologies to mitigate tumorigenic risks and other hurdles. Encouragingly, iPSCs show promising outcomes in regenerative therapies, as evidenced by their successful application in animal models.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organoides / Células Madre Pluripotentes Inducidas Límite: Animals / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organoides / Células Madre Pluripotentes Inducidas Límite: Animals / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza