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Norepinephrine may promote the progression of Fusobacterium nucleatum related colorectal cancer via quorum sensing signalling.
Du, Xinhao; Tang, Zhenzhen; Yan, Li; Zhang, Ling; Zheng, Qiao; Zeng, Xianghao; Hu, Qing; Tian, Qian; Liang, Lanfan; Zhao, Xinyu; Li, Jun; Zhao, Ming; Fu, Xiangsheng.
Afiliación
  • Du X; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Tang Z; Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
  • Yan L; Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
  • Zhang L; Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
  • Zheng Q; Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
  • Zeng X; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Hu Q; Clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, P.R. China.
  • Tian Q; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Liang L; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Zhao X; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Li J; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Zhao M; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
  • Fu X; Department of Gastroenterology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P.R. China.
Virulence ; 15(1): 2350904, 2024 12.
Article en En | MEDLINE | ID: mdl-38725098
ABSTRACT
Fusobacterium nucleatum (F. nucleatum) is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of F. nucleatum in CRC and reveal the underlying mechanism. The results revealed that both norepinephrine and bacterial quorum sensing (QS) molecule auto-inducer-2 (AI-2) were positively associated with the progression of F. nucleatum related CRC (p < 0.01). In vitro studies, norepinephrine induced upregulation of QS-associated genes and promoted the virulence and proliferation of F. nucleatum. Moreover, chronic stress significantly increased the colon tumour burden of ApcMin/+ mice infected with F. nucleatum (p < 0.01), which was decreased by a catecholamine inhibitor (p < 0.001). Our findings suggest that stress-induced norepinephrine may promote the progression of F. nucleatum related CRC via bacterial QS signalling. These preliminary data provide a novel strategy for the management of pathogenic bacteria by targeting host hormones-bacterial QS inter-kingdom signalling.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Transducción de Señal / Norepinefrina / Fusobacterium nucleatum / Percepción de Quorum Límite: Animals / Humans / Male Idioma: En Revista: Virulence Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Transducción de Señal / Norepinefrina / Fusobacterium nucleatum / Percepción de Quorum Límite: Animals / Humans / Male Idioma: En Revista: Virulence Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos