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Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity in REM sleep and verbal memory.
Lui, Kitty K; Dave, Abhishek; Sprecher, Kate E; Chappel-Farley, Miranda G; Riedner, Brady A; Heston, Margo B; Taylor, Chase E; Carlsson, Cynthia M; Okonkwo, Ozioma C; Asthana, Sanjay; Johnson, Sterling C; Bendlin, Barbara B; Mander, Bryce A; Benca, Ruth M.
Afiliación
  • Lui KK; San Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
  • Dave A; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
  • Sprecher KE; Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
  • Chappel-Farley MG; Department of Cognitive Sciences, University of California, Irvine, CA, USA.
  • Riedner BA; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI, USA.
  • Heston MB; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA.
  • Taylor CE; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Carlsson CM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Okonkwo OC; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.
  • Asthana S; Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA, USA.
  • Johnson SC; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
  • Bendlin BB; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Mander BA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Benca RM; Department of Neuroscience, University of Kentucky, Lexington, KY, USA.
Alzheimers Res Ther ; 16(1): 102, 2024 05 09.
Article en En | MEDLINE | ID: mdl-38725033
ABSTRACT

BACKGROUND:

Obstructive sleep apnea (OSA) increases risk for cognitive decline and Alzheimer's disease (AD). While the underlying mechanisms remain unclear, hypoxemia during OSA has been implicated in cognitive impairment. OSA during rapid eye movement (REM) sleep is usually more severe than in non-rapid eye movement (NREM) sleep, but the relative effect of oxyhemoglobin desaturation during REM versus NREM sleep on memory is not completely characterized. Here, we examined the impact of OSA, as well as the moderating effects of AD risk factors, on verbal memory in a sample of middle-aged and older adults with heightened AD risk.

METHODS:

Eighty-one adults (mean age61.7 ± 6.0 years, 62% females, 32% apolipoprotein E ε4 allele (APOE4) carriers, and 70% with parental history of AD) underwent clinical polysomnography including assessment of OSA. OSA features were derived in total, NREM, and REM sleep. REM-NREM ratios of OSA features were also calculated. Verbal memory was assessed with the Rey Auditory Verbal Learning Test (RAVLT). Multiple regression models evaluated the relationships between OSA features and RAVLT scores while adjusting for sex, age, time between assessments, education years, body mass index (BMI), and APOE4 status or parental history of AD. The significant main effects of OSA features on RAVLT performance and the moderating effects of AD risk factors (i.e., sex, age, APOE4 status, and parental history of AD) were examined.

RESULTS:

Apnea-hypopnea index (AHI), respiratory disturbance index (RDI), and oxyhemoglobin desaturation index (ODI) during REM sleep were negatively associated with RAVLT total learning and long-delay recall. Further, greater REM-NREM ratios of AHI, RDI, and ODI (i.e., more events in REM than NREM) were related to worse total learning and recall. We found specifically that the negative association between REM ODI and total learning was driven by adults 60 + years old. In addition, the negative relationships between REM-NREM ODI ratio and total learning, and REM-NREM RDI ratio and long-delay recall were driven by APOE4 carriers.

CONCLUSION:

Greater OSA severity, particularly during REM sleep, negatively affects verbal memory, especially for people with greater AD risk. These findings underscore the potential importance of proactive screening and treatment of REM OSA even if overall AHI appears low.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño REM / Polisomnografía / Apnea Obstructiva del Sueño / Enfermedad de Alzheimer Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Res Ther Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sueño REM / Polisomnografía / Apnea Obstructiva del Sueño / Enfermedad de Alzheimer Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Alzheimers Res Ther Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido