Childhood cancer survivors: current challenges.
An Pediatr (Engl Ed)
; 100(5): 363-375, 2024 May.
Article
en En
| MEDLINE
| ID: mdl-38724403
ABSTRACT
Rates of childhood cancer survival in developed countries have risen to over 80-85 %. In consequence, the population of childhood cancer survivors (CCS) has grown considerably. Nevertheless, CCS present a high morbidity and mortality due to cancer or its treatment, with an increased risk of premature mortality, second primary tumors and late side effects, both physical and psychosocial, all of which decrease the quality of life. Long-term follow-up (LTFU) of CCS is recommended to prevent, detect and treat those health problems. Despite the advances achieved, the management of CCS is still not optimal. Among the areas for improvement discussed in this manuscript are (1) Quantifying the real burden of morbimortality, by implementing new frequency measures (mean cumulative count and cumulative burden), to obtain more accurate assessments, and using simulation models, to determine individual risks; (2) Assessing the impact of risk factors for late side effects, related to the patient, tumor type, treatments, lifestyle, comorbidities, genetics and ageing; (3) Considering the impact of the international harmonisation of long-term follow-up guidelines, to generate homogeneous, evidence-based recommendations and an individualized LTFU and, (4) Challenges to LTFU implementation, considering models of care adapted to patient risk and needs, with special attention to the transition to adult-care follow-up. Finally, we comment on the situation of CCS in Spain and consider future prospects for improving the health and quality of life of this population.
Palabras clave
Calidad de vida; Chemotherapy; Childhood cancer survivor; Guías de seguimiento a largo plazo; Long-term follow-up; Long-term follow-up guidelines; Quality of life; Quimioterapia; Radioterapia; Radiotherapy; Second neoplasms; Seguimiento a largo plazo; Segundas neoplasias; Superviviente de cáncer infantil
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Supervivientes de Cáncer
Límite:
Child
/
Humans
Idioma:
En
Revista:
An Pediatr (Engl Ed)
Año:
2024
Tipo del documento:
Article
Pais de publicación:
España