Age-dependent small fiber neuropathy: Mechanistic insights from animal models.
Exp Neurol
; 377: 114811, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38723859
ABSTRACT
Small fiber neuropathy (SFN) is a common and debilitating disease in which the terminals of small diameter sensory axons degenerate, producing sensory loss, and in many patients neuropathic pain. While a substantial number of cases are attributable to diabetes, almost 50% are idiopathic. An underappreciated aspect of the disease is its late onset in most patients. Animal models of human genetic mutations that produce SFN also display age-dependent phenotypes suggesting that aging is an important contributor to the risk of development of the disease. In this review we define how particular sensory neurons are affected in SFN and discuss how aging may drive the disease. We also evaluate how animal models of SFN can define disease mechanisms that will provide insight into early risk detection and suggest novel therapeutic interventions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Envejecimiento
/
Modelos Animales de Enfermedad
/
Neuropatía de Fibras Pequeñas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Exp Neurol
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos