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Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment.
Kashkooli, Farshad Moradi; Jakhmola, Anshuman; A Ferrier, Graham; Sathiyamoorthy, Krishnan; Tavakkoli, Jahangir Jahan; C Kolios, Michael.
Afiliación
  • Kashkooli FM; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
  • Jakhmola A; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
  • A Ferrier G; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
  • Sathiyamoorthy K; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
  • Tavakkoli JJ; Department of Physics, Toronto Metropolitan University, Toronto, ON, Canada.
  • C Kolios M; Institute for Biomedical Engineering, Science & Technology (iBEST), Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada.
Nanomedicine (Lond) ; 19(13): 1167-1189, 2024.
Article en En | MEDLINE | ID: mdl-38722104
ABSTRACT

Aim:

To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances drug penetration and uptake in tumors. This aims to advance cancer treatment strategies.Materials &

methods:

We developed a multi-physics mathematical model to elucidate and understand the intricate mechanisms governing drug release, transport and delivery. Unique in vitro models (monolayer, multilayer, spheroid) and a tailored US exposure setup were introduced to evaluate drug penetration and uptake.

Results:

The results highlight the potential advantages of US-mediated NSDDSs over conventional NSDDSs and chemotherapy, notably in enhancing drug release and inducing cell death.

Conclusion:

Our sophisticated numerical and experimental methods aid in determining and quantifying drug penetration and uptake into solid tumors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Liberación de Fármacos / Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistemas de Liberación de Medicamentos / Liberación de Fármacos / Neoplasias / Antineoplásicos Límite: Humans Idioma: En Revista: Nanomedicine (Lond) Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido