Your browser doesn't support javascript.
loading
Efgartigimod as rescue treatment in acute phase of neuromyelitis optica spectrum disorder: A Case Report.
Li, Zhizhong; Xu, Qiao; Huang, Jialu; Zhu, Qiyuan; Yang, Xiaolin; Zhang, Mengjie; Zhang, Shaoru; Huang, Siyuan; Yu, Gang; Zheng, Peng; Qin, Xinyue; Feng, Jinzhou.
Afiliación
  • Li Z; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Xu Q; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Huang J; 958th Hospital of the People's Liberation Army, Chongqing, 400038, China.
  • Zhu Q; Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Yang X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Zhang M; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Zhang S; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Huang S; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Yu G; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Zheng P; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Qin X; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Feng J; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Heliyon ; 10(9): e30421, 2024 May 15.
Article en En | MEDLINE | ID: mdl-38720715
ABSTRACT

Introduction:

Neuromyelitis optica spectrum disorder (NMOSD) is a central nervous system demyelinating disease. Current therapy methods, however, have limited effect on acute attacks except for intravenous methylprednisolone (IVMP). Efgartigimod is a first-in-class novel human immunoglobulin G1 (IgG1) Fc fragment approved for the treatment of generalized myasthenia gravis. Its capacity to rapidly decrease serum IgG levels, including pathogenic autoantibodies, positions it as a potentially effective option for managing the acute phase of NMOSD. Case presentation We report the case of a 59-year-old female patient with acute NMOSD, presenting with vision loss and numbness in all four limbs. Despite an initial inadequate response to intravenous methylprednisolone (IVMP), the addition of Efgartigimod to her treatment regimen led to rapid improvement, notably including a significant reduction in serum aquaporin-4 antibody titers, total IgG levels, and inflammation cytokine levels. Furthermore, no adverse events were reported during a four-month follow-up period.

Conclusion:

As an adjunct to glucocorticoid therapy, Efgartigimod has proven effective and safe for this patient. However, to ascertain its potential as a novel therapeutic option for acute NMOSD, larger-scale prospective clinical trials are required.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido