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REMEMProt: a resource of membrane-enriched proteome profiles, their disease associations, and biomarker status.
Aravind, Anjana; Nandakumar, Revathy; Ahmed, Mukhtar; Nisar, Mahammad; Palollathil, Akhina; Kanichery, Anagha; Sreelan, Sourav; Sinan, Kp Munavvar; Balaya, Rex Devasahayam Arokia; Vijayakumar, Manavalan; Prasad, Thottethodi Subrahmanya Keshava; Raju, Rajesh.
Afiliación
  • Aravind A; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Nandakumar R; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Ahmed M; https://ror.org/02f81g417 Department of Zoology, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia.
  • Nisar M; Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India.
  • Palollathil A; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Kanichery A; Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.
  • Sreelan S; Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India.
  • Sinan KM; Yenepoya Institute of Technology, Yenepoya (Deemed to be University), Mangalore, India.
  • Balaya RDA; Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India.
  • Vijayakumar M; Yenepoya Institute of Technology, Yenepoya (Deemed to be University), Mangalore, India.
  • Prasad TSK; Centre for Integrative Omics Data Science (CIODS), Yenepoya (Deemed to be University), Mangalore, India.
  • Raju R; Department of Surgical Oncology, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, India mvijai2013@gmail.com vicechancellor@yenepoya.edu.in.
Life Sci Alliance ; 7(7)2024 Jul.
Article en En | MEDLINE | ID: mdl-38719747
ABSTRACT
The differential expression of plasma membrane proteins is integrally analyzed for their diagnosis, prognosis, and therapeutic applications in diverse clinical manifestations. Necessarily, distinct membrane protein enrichment methods and mass spectrometry platforms are employed for their global and relative quantitation. First of its kind to explore, we compiled membrane-associated proteomes in human and mouse systems into a database named, Resource of Experimental Membrane-Enriched Mass spectrometry-derived Proteome (REMEMProt). It currently hosts 14,626 proteins (9,507 proteins in Homo sapiens; 5,119 proteins in Mus musculus) with information on their membrane-protein enrichment methods, experimental/physiological context of detection in cells or tissues, transmembrane domain analysis, and their current attribution as biomarkers. Based on these annotations and the transmembrane domain analysis in proteins or their binary/complex protein-protein interactors, REMEMProt facilitates the assessment of the plasma membrane localization potential of proteins through batch query. A cross-study enrichment analysis platform is enabled in REMEMProt for comparative analysis of proteomes using novel/modified membrane enrichment methods and evaluation of methods for targeted enrichment of membrane proteins. REMEMProt data are made freely accessible to explore and download at https//rememprot.ciods.in/.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Proteoma / Bases de Datos de Proteínas / Proteómica / Proteínas de la Membrana Límite: Animals / Humans Idioma: En Revista: Life Sci Alliance Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Proteoma / Bases de Datos de Proteínas / Proteómica / Proteínas de la Membrana Límite: Animals / Humans Idioma: En Revista: Life Sci Alliance Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos