The mesopontine tegmentum in reward and aversion: From cellular heterogeneity to behaviour.
Neurosci Biobehav Rev
; 162: 105702, 2024 Jul.
Article
en En
| MEDLINE
| ID: mdl-38718986
ABSTRACT
The mesopontine tegmentum, comprising the pedunculopontine tegmentum (PPN) and the laterodorsal tegmentum (LDT), is intricately connected to various regions of the basal ganglia, motor systems, and limbic systems. The PPN and LDT can regulate the activity of different brain regions of these target systems, and in this way are in a privileged position to modulate motivated behaviours. Despite recent findings, the PPN and LDT have been largely overlooked in discussions about the neural circuits associated with reward and aversion. This review aims to provide a timely and comprehensive resource on past and current research, highlighting the PPN and LDT's connectivity and influence on basal ganglia and limbic, and motor systems. Seminal studies, including lesion, pharmacological, and optogenetic/chemogenetic approaches, demonstrate their critical roles in modulating reward/aversive behaviours. The review emphasizes the need for further investigation into the associated cellular mechanisms, in order to clarify their role in behaviour and contribution for different neuropsychiatric disorders.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Recompensa
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Neurosci Biobehav Rev
Año:
2024
Tipo del documento:
Article
Pais de publicación:
Estados Unidos