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Use of Intravenous Lipid Emulsion Therapy and Insulin in a Case of Tarka Intoxication.
Gün, Emrah; Çiçek, Mahmut; Kafali, Mustafa; Demir, Hüsnü; Arslan, Ilknur; Kendirli, Tanil.
Afiliación
  • Gün E; Department of Pediatric Intensive Care, Adana City Hospital, Adana, Turkey, mrhgn@hotmail.com.
  • Çiçek M; Department of Pediatrics, Adana City Hospital, Adana, Turkey.
  • Kafali M; Department of Pediatrics, Adana City Hospital, Adana, Turkey.
  • Demir H; Department of Pediatric Cardiology, Adana City Hospital, Adana, Turkey.
  • Arslan I; Department of Pediatric Intensive Care, Adana City Hospital, Adana, Turkey.
  • Kendirli T; Department of Pediatric Intensive Care, Ankara University School of Medicine, Ankara, Turkey.
WMJ ; 123(2): 144-146, 2024 May.
Article en En | MEDLINE | ID: mdl-38718248
ABSTRACT

INTRODUCTION:

Tarka (trandolapril/verapamil hydrohloride extended-release) is a fixed-dose combination antihypertensive drug formed from verapamil hydrochloride and trandolapril. Toxicologic manifestations of Tarka overdose are altered mental status, bradycardia, hypotension, atrioventricular block (first-degree), hyperglycemia, metabolic acidosis, and shock. CASE PRESENTATION We report a case of Tarka toxicity in a 2-year-old girl who presented with altered mental status, cardiogenic shock, hypotension, bradycardia, severe metabolic acidosis, hyperglycemia, and first-degree atrioventricular block. We started fluid resuscitation, epinephrine, norepinephrine, and insulin. Because of the patient's hyperlactatemia and hypotension despite standard therapies, we initiated intravenous lipid emulsion (ILE) therapy, after which her condition improved promptly.

DISCUSSION:

Tarka overdose may be life-threatening as it can cause cardiogenic shock. In our patient, the regression of lactate elevation in a short time with ILE therapy and the improvement of her general condition highlight the importance of ILE.

CONCLUSIONS:

ILE is an alternative treatment method for acute lipophilic drug intoxications, such as Tarka.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Verapamilo / Emulsiones Grasas Intravenosas / Sobredosis de Droga / Insulina Límite: Child, preschool / Female / Humans Idioma: En Revista: WMJ Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Verapamilo / Emulsiones Grasas Intravenosas / Sobredosis de Droga / Insulina Límite: Child, preschool / Female / Humans Idioma: En Revista: WMJ Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos