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Potential antiprostatic performance of novel lanthanide-complexes based on 5-nitropicolinic acid.
García-García, Amalia; Cristobal-Cueto, Pablo; Hidalgo, Tania; Vitórica-Yrezábal, Iñigo J; Rodríguez-Diéguez, Antonio; Horcajada, Patricia; Rojas, Sara.
Afiliación
  • García-García A; Department of Inorganic Chemistry, Faculty of Science, University of Granada, Av. Fuente Nueva S/N, 18071, Granada, Spain.
  • Cristobal-Cueto P; Advanced Porous Material Unit, IMDEA Energy Institute, Av. Ramón de La Sagra 3, 28935, Móstoles, Madrid, Spain.
  • Hidalgo T; Advanced Porous Material Unit, IMDEA Energy Institute, Av. Ramón de La Sagra 3, 28935, Móstoles, Madrid, Spain.
  • Vitórica-Yrezábal IJ; Department of Inorganic Chemistry, Faculty of Science, University of Granada, Av. Fuente Nueva S/N, 18071, Granada, Spain.
  • Rodríguez-Diéguez A; Department of Inorganic Chemistry, Faculty of Science, University of Granada, Av. Fuente Nueva S/N, 18071, Granada, Spain.
  • Horcajada P; Advanced Porous Material Unit, IMDEA Energy Institute, Av. Ramón de La Sagra 3, 28935, Móstoles, Madrid, Spain. patricia.horcajada@imdea.org.
  • Rojas S; Department of Inorganic Chemistry, Faculty of Science, University of Granada, Av. Fuente Nueva S/N, 18071, Granada, Spain. srojas@ugr.es.
J Biol Inorg Chem ; 29(3): 331-338, 2024 04.
Article en En | MEDLINE | ID: mdl-38717473
ABSTRACT
Two new lanthanide-complexes based on the 5-nitropicolinate ligand (5-npic) were obtained and fully characterized. Single-crystal X-ray diffraction revealed that these compounds are isostructural to a Dy-complex, previously published by us, based on dinuclear monomers link together with an extended hydrogen bond network, providing a final chemical formula of [Ln2(5-npic)6(H2O)4]·(H2O)2, where Ln = Dy (1), Gd (2), and Tb (3). Preliminary photoluminescent studies exhibited a ligand-centered emission for all complexes. The potential antitumoral activity of these materials was assayed in a prostatic cancer cell line (PC-3; the 2nd most common male cancerous disease), showing a significant anticancer activity (50-60% at 500 µg·mL-1). In turn, a high biocompatibility by both, the complexes and their precursors in human immunological HL-60 cells, was evidenced. In view of the strongest toxic effect in the tumoral cell line provided by the free 5-npic ligand (~ 40-50%), the overall anticancer complex performance seems to be triggered by the presence of this molecule.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Picolínicos / Elementos de la Serie de los Lantanoides / Antineoplásicos Límite: Humans / Male Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Picolínicos / Elementos de la Serie de los Lantanoides / Antineoplásicos Límite: Humans / Male Idioma: En Revista: J Biol Inorg Chem Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Alemania