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Comparison of four D-dimer assays in the context of venous thromboembolism in the emergency department.
Del Ben, Fabio; Fontanini, Elisabetta; Azzarini, Gabriella; Arini, Marina; Marini, Christian; Poli, Giovanni; Pradella, Paola; Parusso, Serena; Santarossa, Liliana; Targa, Federica; Zardo, Lorena; Giacomello, Roberta; Morelli, Benedetto.
Afiliación
  • Del Ben F; CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.
  • Fontanini E; Dipartimento di Area Medica, Università degli Studi di Udine, Dipartimento di Medicina di Laboratorio, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
  • Azzarini G; Componente del gruppo di studio Emostasi e Trombosi della Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica-Medicina di Laboratorio (SIBioC), Milano, Italy.
  • Arini M; Laboratorio Analisi, Dipartimento di Patologia Clinica, Azienda ULSS 3 Serenissima, Ospedale Dell'Angelo, Venezia-Mestre, Italy.
  • Marini C; Dipartimento Area di Emergenza, Azienda Sanitaria Universitaria Friuli Centrale, Ospedale S. Daniele del Friuli, San Daniele del Friuli, Italy.
  • Poli G; UOC Laboratorio Analisi, Azienda Ospedaliera Universitaria Integrata di Verona, Ospedale Policlinico Borgo Roma, Verona, Italy.
  • Pradella P; Laboratorio di Patologia dell'Emostasi, Dipartimento di Medicina Trasfusionale Azienda Sanitaria Universitaria Giuliano Isontina, Ospedale di Cattinara, Trieste, Italy.
  • Parusso S; Dipartimento di Medicina Trasfusionale, Azienda Sanitaria Friuli Occidentale, Ospedale Santa Maria degli Angeli, Pordenone, Italy.
  • Santarossa L; Centro per le malattie emorragiche e trombotiche, Dipartimento di Medicina Trasfusionale, Azienda Sanitaria Friuli Occidentale, Ospedale Santa Maria degli Angeli, Pordenone, Italy.
  • Targa F; Laboratorio Centrale di Patologia Clinica, Azienda Sanitaria dell'Alto Adige, Ospedale di Bolzano, Bolzano, Italy.
  • Zardo L; Dipartimento di Medicina Specialistica, Azienda ULSS 2 Marca Trevigiana, Ospedale Ca' Foncello, UOC Medicina di Laboratorio, Ospedale di Castelfranco Veneto, Treviso, Italy.
  • Giacomello R; Dipartimento di Area Medica, Università degli Studi di Udine, Dipartimento di Medicina di Laboratorio, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy.
  • Morelli B; Coordinatore del gruppo di studio Emostasi e Trombosi della Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica-Medicina di Laboratorio (SIBioC), Milano, Italy.
Int J Lab Hematol ; 2024 May 08.
Article en En | MEDLINE | ID: mdl-38716760
ABSTRACT

INTRODUCTION:

This observational study conducted across seven emergency care units compares the efficacy of four D-dimer detection methods, namely HemosIL D-dimer HS (HS), HemosIL D-dimer HS-500 (HS-500), VIDAS D-dimer (VIDAS), and HemosIL AcuStar D-dimer (ACUSTAR). The primary focus is on patients with a clinical suspicion of deep venous thrombosis (DVT) or pulmonary embolism (PE).

METHODS:

A total of 149 samples were collected from patients with suspected DVT or PE. The confirmation of DVT/PE was based on calf ultrasound or computed tomography-Angiography. Direct comparisons were made between the different detection methods, considering both their analytical performance and clinical utility. Additionally, the impact of an age-adjusted cut-off on the diagnostic accuracy of each method was assessed.

RESULTS:

The results revealed comparable negative predictive value, sensitivity, and specificity across the methods, with a notable exception of increased specificity for HS compared with HS-500 (50.8% vs. 41.5%, p = 0.03). Further analysis incorporating an age-adjusted cut-off demonstrated a significant improvement in specificity for HS. When using the age-adjusted cut-off, HS exhibited a substantial increase in specificity compared with HS-500 (63.1% vs. 49.2%, p = 0.004) and demonstrated significantly higher specificity compared with VIDAS (63.1% vs. 53.8%, p = 0.04).

CONCLUSION:

The study emphasizes the nonuniversal effect of an age-adjusted cut-off and discusses the potential necessity for different cut-off values, particularly in the case of HS-500. These findings contribute to the understanding of D-dimer detection methods in the context of DVT and PE, providing insights into their relative performances and the potential optimization through age-adjusted cut-offs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Lab Hematol Asunto de la revista: HEMATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido