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Evaluation of the effect of Modafinil in the improvement of the level of consciousness in patients with COVID-19 encephalopathy: A randomized controlled trial.
Talebi Kiasari, Fatemeh; Naghshbandi, Mobin; Emamikhah, Maziar; Moradi Moghaddam, Omid; Niakan Lahiji, Mohammad; Rohani, Mohammad; Yazdi, Narges; Movahedi, Hamidreza; Amanollahi, Alireza; Irandoost, Pardis; Ghafoury, Roya.
Afiliación
  • Talebi Kiasari F; Department of Neurology, Hazrat-e Rasool General Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Naghshbandi M; School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Emamikhah M; Department of Neurology, Hazrat-e Rasool General Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Moradi Moghaddam O; Trauma and Injury Research Center, Critical Care Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Niakan Lahiji M; Trauma and Injury Research Center, Critical Care Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Rohani M; Department of Neurology, Hazrat-e Rasool General Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Yazdi N; Department of Neurology, Hazrat-e Rasool General Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Movahedi H; School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Amanollahi A; Trauma and Injury Research Center, Critical Care Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Irandoost P; Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Ghafoury R; School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Neuropsychopharmacol Rep ; 2024 May 08.
Article en En | MEDLINE | ID: mdl-38715471
ABSTRACT

AIM:

COVID-19 can lead to encephalopathy and loss of consciousness. This double-blinded randomized clinical trial conducted in Tehran, Iran, aimed to assess the potential effectiveness of modafinil in patients with COVID-19-related encephalopathy.

METHODS:

Nineteen non-intubated COVID-19 patients with encephalopathy were randomized into two groups a treatment group receiving crushed modafinil tablets and a placebo group receiving starch powder. Modafinil was administered at a dose of 100 mg every 2 h, reaching a peak dosage of 400 mg. The level of consciousness was assessed using the Glasgow Coma Score (GCS) at multiple time points on the day of medication administration. The trial was registered under IRCT20170903036041N3 on 23/5/2021.

RESULTS:

The average age in the modafinil and placebo groups was 75.33 and 70 years, respectively. No significant differences were observed between the two groups in terms of chronic conditions, clinical symptoms, or laboratory data. GCS scores were similar between the groups at baseline (p-value = 0.699). After four doses of modafinil, GCS scores were slightly higher in the treatment group, but this difference was not statistically significant (p-value = 0.581). GCS scores after each round of drug administration didn't significantly differ between the treatment and placebo groups (p-value = 0.908).

CONCLUSION:

Modafinil exhibited a slight improvement in the level of consciousness among COVID-19 patients with encephalopathy, although this improvement did not reach statistical significance when compared to the control group. Further research with larger sample sizes and longer treatment durations is recommended to explore modafinil's potential benefits in managing altered consciousness in COVID-19 patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuropsychopharmacol Rep Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Neuropsychopharmacol Rep Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos