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Traditional and non-traditional lipid parameters as risk factors for sudden sensorineural hearing loss.
Chen, Xiaoyan; Zheng, Zhong; Liu, Ximeng; Huang, Jianuo; Xie, Daoyu; Feng, Yanmei.
Afiliación
  • Chen X; Shanghai Jiao Tong University School of Medicine affiliated Sixth People's Hospital, Department of Otolaryngology-Head and Neck Surgery, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
  • Zheng Z; Shanghai Jiao Tong University School of Medicine affiliated Sixth People's Hospital, Department of Otolaryngology-Head and Neck Surgery, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
  • Liu X; Hangzhou Normal University, Zhejiang Province, China.
  • Huang J; Hangzhou Normal University, Zhejiang Province, China.
  • Xie D; Affiliated Hospital of Hangzhou Normal University, Department of Otolaryngology-Head and Neck Surgery, Zhejiang Province, China. Electronic address: xiedaoyu_2010@163.com.
  • Feng Y; Shanghai Jiao Tong University School of Medicine affiliated Sixth People's Hospital, Department of Otolaryngology-Head and Neck Surgery, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China. Electronic address: ymfeng@sjtu.edu.cn.
Braz J Otorhinolaryngol ; 90(4): 101435, 2024.
Article en En | MEDLINE | ID: mdl-38714080
ABSTRACT

OBJECTIVE:

The purpose was to explore the effects of traditional and non-traditional lipid parameters on Sudden Sensorineural Hearing Loss (SSNHL).

METHODS:

The study included 452 patients diagnosed with SSNHL, among whom 206 patients had a level of hearing improvement ≥10 dB after one month of follow-up. A propensity score-matched (21) control group was used. Conditional and unconditional logistic regression were used to analyze the risk factors for SSNHL.

RESULTS:

Patients with SSNHL had a higher risk of concomitant hypertension and elevated atherosclerogenic lipid levels, with apolipoprotein B and apolipoprotein E identified as independent risk factors for the onset of SSNHL. Additionally, the Lipid Comprehensive Index (LCI) was an independent risk factor for the degree of hearing loss. A positive linear correlation was revealed between triglyceride, non-high-density lipoprotein cholesterol, atherogenic index, Castelli risk index, atherogenic index of plasma, LCI and hearing loss. However, no linear relationship was observed between hearing gain and any lipid parameters. When Total Cholesterol (TC) was in the range of borderline high, the treatment effect was the best. However, the statistical significance disappeared upon adjusting for confounding factors.

CONCLUSION:

Patients with SSNHL exhibited markedly dysregulated lipid metabolism. Elevated serum lipid levels may be a causative factor in auditory impairment and can influence the extent of hearing loss. Promptly improving cochlear microcirculation may benefit patients with borderline elevated TC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida Auditiva Súbita / Pérdida Auditiva Sensorineural / Lípidos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pérdida Auditiva Súbita / Pérdida Auditiva Sensorineural / Lípidos Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Braz J Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil