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MRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children.
Hodgdon, Elizabeth A; Anderson, Ryan; Azzawi, Hussein Al; Wilson, Tony W; Calhoun, Vince D; Wang, Yu-Ping; Solis, Isabel; Greve, Douglas N; Stephen, Julia M; Ciesielski, Kristina T R.
Afiliación
  • Hodgdon EA; Pediatric Neuroscience Laboratory, Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Anderson R; Pediatric Neuroscience Laboratory, Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Azzawi HA; Pediatric Neuroscience Laboratory, Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Wilson TW; Institute of Human Neuroscience, Boys Town National Research Hospital, 14090 Mother Teresa Lane, Boys Town, NE 68010, USA.
  • Calhoun VD; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd N.E., Albuquerque, NM 87106, USA; Tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State, Georgia Tech, Emory, Atlanta, GA, USA.
  • Wang YP; Department of Biomedical Engineering, Tulane University, 6823 St. Charles Ave, New Orleans, LA 70118, USA.
  • Solis I; Pediatric Neuroscience Laboratory, Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA.
  • Greve DN; MGH/MIT Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Stephen JM; Mind Research Network and Lovelace Biomedical and Environmental Research Institute, 1101 Yale Blvd N.E., Albuquerque, NM 87106, USA.
  • Ciesielski KTR; Pediatric Neuroscience Laboratory, Psychology Clinical Neuroscience Center, Department of Psychology, University of New Mexico, Albuquerque, NM 87131, USA; MGH/MIT Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Bo
Dev Cogn Neurosci ; 67: 101385, 2024 Jun.
Article en En | MEDLINE | ID: mdl-38713999
ABSTRACT

INTRODUCTION:

The human cerebellum emerges as a posterior brain structure integrating neural networks for sensorimotor, cognitive, and emotional processing across the lifespan. Developmental studies of the cerebellar anatomy and function are scant. We examine age-dependent MRI morphometry of the anterior cerebellar vermis, lobules I-V and posterior neocortical lobules VI-VII and their relationship to sensorimotor and cognitive functions.

METHODS:

Typically developing children (TDC; n=38; age 9-15) and healthy adults (HAC; n=31; 18-40) participated in high-resolution MRI. Rigorous anatomically informed morphometry of the vermis lobules I-V and VI-VII and total brain volume (TBV) employed manual segmentation computer-assisted FreeSurfer Image Analysis Program [http//surfer.nmr.mgh.harvard.edu]. The neuropsychological scores (WASI-II) were normalized and related to volumes of anterior, posterior vermis, and TBV.

RESULTS:

TBVs were age independent. Volumes of I-V and VI-VII were significantly reduced in TDC. The ratio of VI-VII to I-V (∼60%) was stable across age-groups; I-V correlated with visual-spatial-motor skills; VI-VII with verbal, visual-abstract and FSIQ.

CONCLUSIONS:

In TDC neither anterior I-V nor posterior VI-VII vermis attained adult volumes. The "inverted U" developmental trajectory of gray matter peaking in adolescence does not explain this finding. The hypothesis of protracted development of oligodendrocyte/myelination is suggested as a contributor to TDC's lower cerebellar vermis volumes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cognición / Vermis Cerebeloso Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Dev Cogn Neurosci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Cognición / Vermis Cerebeloso Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Dev Cogn Neurosci Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos