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Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting.
Cho, Hana; Huh, Kang Moo; Cho, Hyun Ji; Kim, Bogeon; Shim, Min Suk; Cho, Yong-Yeon; Lee, Joo Young; Lee, Hye Suk; Kwon, Young Jik; Kang, Han Chang.
Afiliación
  • Cho H; Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. hckang@catholic.ac.kr.
  • Huh KM; Department of Polymer Science and Engineering & Materials Science and Engineering, Chungnam National University, Daejeon 34134, Republic of Korea.
  • Cho HJ; Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. hckang@catholic.ac.kr.
  • Kim B; Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. hckang@catholic.ac.kr.
  • Shim MS; Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
  • Cho YY; Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. hckang@catholic.ac.kr.
  • Lee JY; Regulated Cell Death (RCD) Control Material Research Institute, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
  • Lee HS; Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. hckang@catholic.ac.kr.
  • Kwon YJ; Regulated Cell Death (RCD) Control Material Research Institute, The Catholic University of Korea, Bucheon, 14662, Republic of Korea.
  • Kang HC; Department of Pharmacy, College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, Republic of Korea. hckang@catholic.ac.kr.
Biomater Sci ; 12(12): 3045-3067, 2024 Jun 11.
Article en En | MEDLINE | ID: mdl-38712883
ABSTRACT
Various strategies at the microscale/nanoscale have been developed to improve oral absorption of therapeutics. Among them, gastrointestinal (GI)-transporter/receptor-mediated nanosized drug delivery systems (NDDSs) have drawn attention due to their many benefits, such as improved water solubility, improved chemical/physical stability, improved oral absorption, and improved targetability of their payloads. Their therapeutic potential in disease animal models (e.g., solid tumors, virus-infected lungs, metastasis, diabetes, and so on) has been investigated, and could be expanded to disease targeting after systemic/lymphatic circulation, although the detailed paths and mechanisms of endocytosis, endosomal escape, intracellular trafficking, and exocytosis through the epithelial cell lining in the GI tract are still unclear. Thus, this review summarizes and discusses potential GI transporters/receptors, their absorption and distribution, in vivo studies, and potential sequential targeting (e.g., oral absorption and disease targeting in organs/tissues).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas Límite: Animals / Humans Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas Límite: Animals / Humans Idioma: En Revista: Biomater Sci Año: 2024 Tipo del documento: Article Pais de publicación: Reino Unido