A retrospective budget impact analysis of fidaxomicin treatment for Clostridioides difficile infections (CDI) in Germany.
Expert Rev Pharmacoecon Outcomes Res
; 24(8): 933-942, 2024 Oct.
Article
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| MEDLINE
| ID: mdl-38712561
ABSTRACT
BACKGROUND:
Clostridioides difficile is the most common cause of healthcare-associated diarrhea. Research suggests that treating C. difficile infections (CDI) with fidaxomicin (FDX) is more effective than vancomycin (VAN), with potential cost savings. The objective was to calculate the budget impact of FDX treatment compared to VAN from a German payer perspective. RESEARCH DESIGN ANDMETHODS:
The analysis used real-world data of patients discharged from University Hospital Cologne between Jan-01-2018 and Dec-31-2019. We identified recurrent and non-recurrent CDI cases and calculated direct treatment costs based on G-DRG flat rates. To calculate average costs per treatment and the budget impact, recurrence probabilities for VAN and FDX were taken from published evidence (28-day and 90-day scenarios).RESULTS:
Totally, 475 cases were analyzed, thereof 421 non-recurrent, causing mean costs of 32,901 per case (95% CI 27.752-38.050). Thirty-two patients experienced a recurrence within 28 days, yielding mean costs of 10,952 (95% CI 5.627-16.277) for their additional hospital stay. The resulting budget impact was 1,303 (95% CI 670-1.937) in favor of FDX, ranging from 148.34 to 2,190.30 in scenario analyses.CONCLUSION:
The analysis indicates FDX treatment can lead to cost savings compared to VAN. Future research should focus on specific patient groups, such as refractory CDI patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Expert Rev Pharmacoecon Outcomes Res
Asunto de la revista:
FARMACOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Reino Unido