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Does vitamin D supplementation benefit patients with type 1 diabetes mellitus who are vitamin D deficient? A study was performed at the Sudan Childhood Diabetes Center from 2019 to 2022.
Suliman, Hiba Abdelmunim; Elkhawad, Abdalla Omer; Babiker, Omer Osman; Alhaj, Yousif Mohammed; Eltom, Kholod Hamad; Elnour, Asim Ahmed.
Afiliación
  • Suliman HA; Department of Clinical Pharmacy, The National Ribat University, Khartoum, Sudan.
  • Elkhawad AO; Department of Pharmacology, University of Medical Science and Technology, Khartoum, Sudan.
  • Babiker OO; Sudan Childhood Diabetes Center, Khartoum, Sudan.
  • Alhaj YM; Faculty of Medicine, Omdurman Islamic University, Omdurman, Sudan.
  • Eltom KH; Faculty of Medicine, Karary University, Omdurman, Sudan.
  • Elnour AA; Department of Pharmaceutical Care, Dr Abdulrahman Bakhsh Hospital, Jeddah, Saudi Arabia.
SAGE Open Med ; 12: 20503121241242931, 2024.
Article en En | MEDLINE | ID: mdl-38711469
ABSTRACT

Objectives:

Type 1 diabetes mellitus is a chronic autoimmune disease caused by insufficient production of insulin. Many studies have linked type 1 diabetes mellitus to vitamin D3 deficiency. We investigated the prevalence of vitamin D deficiency in Sudanese children and adolescents with type 1 diabetes mellitus and assessed the impact of vitamin D deficiency treatment on their glycemic control.

Methods:

In 2019-2022, we conducted a quasi-experimental study on 115 children with type 1 diabetes mellitus (1-19 years old) at the Sudan Childhood Diabetes Center. Vitamin D supplements were given orally to deficient patients for 3 months. The concentrations of hemoglobin A1c, fasting blood glucose, insulin dosage, and vitamin D (25-hydroxyvitamin D (25(OH)D)) were measured before and after vitamin D3 administration. One-way ANOVA and paired sample t-tests were used to evaluate the effect of supplementation.

Results:

Only 27% of type 1 diabetes mellitus children were deficient in vitamin D, whereas 31.1% were inadequate and 40.9% were sufficient. The administration of vitamin D supplements slightly improved hemoglobin A1c levels in 67.7% of the patients, but the difference was not significant (mean 10.8 ± 2.1% before, 10.1 ± 2.5% after, p0.05 = 0.199). However, there was a significant decrease in the fasting blood glucose level (mean 174.978.5-136.759.1 ng/ml; p0.05 = 0.049). Vitamin D levels were significantly increased after treatment (mean = 49.6 ng/mL; t-test = -11.6, 95% CI 40.8-(-28.6); p0.05 = 0.000). After vitamin D3 supplementation, 25.8% of individuals changed their insulin dosage; however, there was no significant variation in insulin needs.

Conclusions:

The prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes mellitus in Sudan is relatively high; incorporating vitamin D supplements in their treatment plan may improve their glycemic control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: SAGE Open Med Año: 2024 Tipo del documento: Article País de afiliación: Sudán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: SAGE Open Med Año: 2024 Tipo del documento: Article País de afiliación: Sudán Pais de publicación: Reino Unido