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Incidence and Association of Uveitis with COVID-19 Vaccination: A Systematic Review and Meta-Analysis.
Padhi, Bijaya K; Gupta, Parul Chawla; Al Kaabi, Nawal A; Al-Subaie, Maha F; Alrasheed, Hayam A; Sulaiman, Tarek; Rabaan, Ali A; Khatib, Mahalaqua Nazli; Gaidhane, Shilpa; Zahiruddin, Quazi Syed; Dziedzic, Arkadiusz; Satapathy, Prakasini; Fraj, Najat J; Aldrazi, Fatimah A; Kukreti, Neelima; Rustagi, Sarvesh; Abu Serhan, Hashem.
Afiliación
  • Padhi BK; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Gupta PC; Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
  • Al Kaabi NA; College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates.
  • Al-Subaie MF; Sheikh Khalifa Medical City, Abu Dhabi Health Services Company (SEHA), Abu Dhabi, United Arab Emirates.
  • Alrasheed HA; Research Center, Dr. Sulaiman Alhabib Medical Group, Riyadh, Saudi Arabia.
  • Sulaiman T; Department of Infectious Diseases, Dr. Sulaiman Alhabib Medical Group, Riyadh, Saudi Arabia.
  • Rabaan AA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Khatib MN; Department of Pharmacy Practice, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Gaidhane S; Infectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh, Saudi Arabia.
  • Zahiruddin QS; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
  • Dziedzic A; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.
  • Satapathy P; Department of Public Health and Nutrition, The University of Haripur, Haripur, Pakistan.
  • Fraj NJ; Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.
  • Aldrazi FA; One Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India.
  • Kukreti N; South Asia Infant Feeding Research Network (SAIFRN), Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India.
  • Rustagi S; Department of Conservative Dentistry with Endodontics, Medical University of Silesia, Katowice, Poland.
  • Abu Serhan H; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Ophthalmic Epidemiol ; : 1-9, 2024 May 06.
Article en En | MEDLINE | ID: mdl-38709174
ABSTRACT

PURPOSE:

In the wake of the COVID-19 pandemic, vaccines have been pivotal in curbing disease spread and severity. However, concerns over post-vaccination adverse events, including uveitis, an inflammatory ocular condition, have been noted. This systematic review and meta-analysis aimed to evaluate the incidence and association of uveitis following COVID-19 vaccination.

METHODS:

A literature search was performed across several databases on October 21, 2023. Human studies examining the incidence of uveitis post-COVID-19 vaccination were included. The Newcastle-Ottawa Scale was used for quality appraisal of the included studies. Meta-analysis was performed to assess the overall incidence of uveitis and the relative risk of developing the condition post-vaccination. All statistical analyses were performed using R software version 4.3.

RESULTS:

Six studies involving over 2 billion vaccine doses were included. The overall incidence of uveitis was 0.016% (95% CI 0.010 to 0.026). No significant association was found between vaccination and the onset of uveitis (Relative Risk 1.45 (95% CI 0.82 to 2.57, p = 0.12) from four studies. The evidence quality was rated very low due to the limited number of studies and imprecision.

CONCLUSION:

This analysis indicates a low incidence of uveitis following COVID-19 vaccination and no significant association with the vaccine. The findings are constrained by the small number of studies and low certainty of evidence, underscoring the need for further research. Comprehensive and longitudinal studies are necessary to confirm these findings and reinforce public confidence in COVID-19 vaccination programs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ophthalmic Epidemiol Asunto de la revista: EPIDEMIOLOGIA / OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ophthalmic Epidemiol Asunto de la revista: EPIDEMIOLOGIA / OFTALMOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido